Sandra McIntire (name while pulling a con)
Angela Monroe (name while pulling a con)
Sabrina Santiago (while investigating a case)
Susan Zackin (while investigating a case)
Born May 11, 1980 at 7:23 a.m.
Partner in McCall and Jackal Private Investigations
Former assistant to Todd Manning at Manning Enterprises (undercover work)
Card shark in the Haunted Star casino
Former maid at the Port Charles Hotel
Petty thief [prior to 2003]
122 Harbor View Drive, Port Charles, New York (Harbor View Towers, Penthouse #2)
Formerly 55 Cherry Lane, Port Charles, New York
Formerly Loft #346, Port Charles, New York
Formerly 122 Harbor View Drive, Port Charles, New York (Harbor View Towers, Penthouse #2)
Formerly aboard Lazarus III, a yacht
Five illegal marriages under various aliases
Cody McCall (father; via adoption; deceased)
Evelyn Bass (mother; via adoption; deceased)
Alexis Davis (biological mother)
Julian Jerome (biological father)
Helena Cassadine (step-grandmother)
Mikkos Cassadine (biological grandfather)
Kristin Nilsson (biological grandmother; deceased)
Victor Jerome (biological grandfather; deceased)
Jack McCall (great-grandfather; via adoption; deceased)
Daniel McCall (older brother; via adoption; deceased)
Lucas Jones (biological half-brother)
Kristina Davis (biological maternal half-sister)
Molly Lansing (biological maternal half-sister)
Olivia St. John (biological aunt; deceased)
Evan Jerome (biological uncle; deceased)
Stavros Cassadine (biological uncle; deceased)
Stefan Cassadine (biological uncle; deceased)
Ava Jerome (biological aunt)
Dino (biological uncle)
Kristina Cassadine (biological aunt; deceased)
Nikolas Cassadine (biological cousin)
Lauren Katherine "Kiki" Jerome (biological cousin)
Anthony Cassadine (biological great-uncle; deceased)
Victor Cassadine (biological great-uncle; deceased)
Spencer Cassadine (biological cousin)
Petros Cassadine (cousin)
Baby Girl* McCall (daughter; with Sonny; deceased; Nov 8, 2004)
Rafe Kovich, Jr. (foster son; deceased)
*Samantha had wanted to call her Lila, but the baby was buried as Baby Girl McCall.
Dated the leader of a grand theft auto ring
Jasper Jacks (lovers)
Sonny Corinthos (affair)
Coleman Ratcliffe (flirtation)
Jason Morgan) [Engaged: Jan 17, 2005; broke up: Jul 2007]
Ric Lansing (affair)
Lucas Lorenzo "Lucky" Spencer Jr. (affair)
Jason Morgan (lovers)
John McBain (kissed)
Robert "Franco" Frank (while he believed he was Jason) [kissed]
Silas Clay (affair)
Patrick Drake (lovers)
Assumed aliases, married five different men, and stole their fortunes [prior to 2003 arrival]
Tried for the murder of Bill Monroe - found not guilty/self-defense [prior to 2003 arrival]
Arson [prior to 2003 arrival; charges dropped when it was revealed her half-brother had started the fire]
Murder; set a fire that killed her mother [prior to 2003 arrival; charges dropped when it was revealed her brother had started the fire]
Pick-pocketing [prior to 2003 arrival]
Charged with 19 counts of grand auto theft [prior to 2003 arrival; charges dropped in exchange for her testimony against the leader of the grand theft auto ring, her ex-boyfriend]
Entered pleas of no contest to multiple counts of petty theft and fraud in several states [prior to 2003 arrival; never convicted]
Has a history of bad debt [prior to 2003 arrival]
Pleaded no contest to solicitation in Texas 
Faked a suicide to break out of a small-town jail [Oct 1, 2003]
Stole the jack of diamonds, a card that was a part of the Dead-Man's Hand, from Jax's apartment [Oct 2003]
Threatened to shoot Jax [Oct 2003]
Trespassing; sneaked into the Quartermaine Mansion [Oct 2003]
Drugged Jax and then stole the two cards he had from the Dead-Man's Hand set [Oct 2003]
Impersonated a math tutor to con Georgie, then stole the other three cards from her room [Oct 2003]
Attended an illegal auction; was present while Luke was auctioning off the Dead-Man's Hand [Oct 31, 2003]
Broke into Jax's car [Nov 2003]
Sabotaged Jax's car [Nov 2003]
Arrested for aiding and abetting Sonny Corinthos [Dec 2, 2003]
Stole the sunken Courage's treasure from her father, Cody [Dec 30, 2003]
Took out a Taser switch and shocked Luke in the back of the neck to knock him out [Feb 5, 2004]
Stole the Azure Key's treasure from Luke [Feb 5, 2004]
Arrested in the kidnapping of Kristina Davis-Corinthos [Feb 2005]
Escaped FBI custody [Feb 2005]
Helped Jason spirit Michael out of town before Michael could be arrested for A.J.'s murder, which they believed he'd committed [Jul 2005]
Broke into offices of the school Alexis went to [Mar 2006]
Escaped police custody [Nov 2006]
Shot and killed Diego Alcazar when he went after her and Jason [Nov 17, 2006]
Witnessed Jake Spencer's kidnapping and did nothing [Jun 2007]
Lied to the police when questioned about Jake's kidnapping [Jun 2007]
Hired two armed goons to terrorize Elizabeth Webber and her children in the park [Aug 2007]
Fell into a mineshaft and injured her hip [Nov 2008]
Stole from the police department the gun that Sonny had used to shoot Dante [Feb 3, 2010]
Rendered two security guards at the Crichton-Clark facility unconscious [Mar 3, 2014]
Impersonated Sabrina Santiago and hacked into the computer system at Crichton-Clark medical facility [Aug 4, 2014]
Assaulted William, an employee at Crichton-Clark medical facility [Aug 6, 2014]
Suffered from hypothermia while attempting to salvage the sunken Cassadine freighter [Dec 17, 2003]
Hospitalized after an explosion occurred underwater while she was scuba diving [Dec 26, 2003]
Felt weak after being bit by a scorpion [Jan 5, 2004]
Knocked unconscious after an explosion occurred in an Azure Key cave [Jan 13, 2004]
Stabbed by a person who had just planted an explosive in Sonny's limo [Mar 16, 2004]
Hospitalized after the premature birth of her daughter [Nov 2004]
Fell ill during the encephalitis plague that hit Port Charles [Jan/Feb 2006]
Shot by Manny Ruiz, suffered extensive damage to her uterus [May 2006]
Minor injuries following Metro-Court hostage crisis [Apr 2007]
Attacked by the Text Message Killer [Feb 2008]
Victim of hit-and-run [Feb 2008]
Kidnapped and drugged [Feb 2011]
Critically injured in a limo explosion; temporarily deaf as a result [Feb 25, 2011]
Suffered fainting/dizzy spells [Feb 2011]
Raped by Franco [Nov 2011]
Underwent fertility reconstruction surgery [May 5, 2011]
Hospitalized after she experienced stomach cramping [Jun 17, 2011]
Drugged by Franco [Nov 4, 2011]
Led to believe she was raped by Franco [Nov 7, 2011 (learned she had not been raped; May 29, 2013)]
Rendered unconscious on a cabin floor after giving birth [Jun 4, 2012; Jun 1, 2012 on the show]
Fainted during a dizzy spell while sickened with a fever from the toxin in the water supply; treated for a laceration on her head [Sep 5, 2012]
Rendered unconscious after an altercation with Franco as he impersonated Jason [Jul 22, 2013]
Rendered two security guards at the Crichton-Clark facility unconscious [Mar 3, 2014]
Bruised and sore after being held at gunpoint by Jake Doe (name Jason Morgan used while experiencing amnesia and under Helena Cassadine's mind control) [Dec 8, 2014]
Samantha "Sam" McCall followed Jax to Port Charles in search of a set of cards called the "Dead Man's Hand." They were the cards Wild Bill Hickok had been holding when he was killed, supposedly by a member of the McCall family. Jax hoped to deliver the cards to his father in order to restore his will to live, whereas Sam hoped to destroy the cards which had caused her family generations of bad luck. They met in pursuit of the jack of diamonds card and they swindled the card away from the other back and forth repeatedly. Sam and Jax decided to temporarily team up after a third party, A.J. Quartermaine, joined the quest for the card.
A.J. had the other four cards and a battle for possession of the cards ensued. Luke Spencer, Quartermaine family members Tracy, Dillon, and Skye, along with Georgie Jones all held some or all of the cards briefly at one time. During the game of cat and mouse, an attraction developed between Jax and Sam. Jax eventually ended up with the cards but Sam made one final attempt to steal them back. However, her efforts left them stranded in the desert. When they made it back into civilization, Sam made a few more attempts to get the cards, including disabling Jax's car. She changed her mind about destroying the cards after Jax convinced her that the cards were lucky. Jax won her a yacht at the casino and they made love.
Sam joined Jax at his father's bedside but his father passed away opening his eyes briefly to see his son. She was plagued with guilt because she had prevented Jax from arriving at the hospital in time to save John. That night, Sam gave Jax comfort and they made love. However, Jax received a phone call, and he learned that Sam had sabotaged his car. Jax began pushing Sam away. Jax told Sam to take the Dean Man's Hand and leave town. Despite the opportunity, Sam didn't take the cards.
The cards changed hands a few more times but Sam wanted nothing to do with them when they were in her possession. Instead, she wanted Jax back because she had developed genuine feelings for him. Jax wanted nothing to do with her and they became adversaries once again after her ownership of the yacht was questioned.
Though Sam washed her hands of the cards, she found herself in another sticky situation. Sam was driving down the street when Sonny Corinthos, who had just tried to kill Lorenzo Alcazar, ran right in front of her truck and stopped her. Sonny then took Sam hostage and forced her to drive away from the crime scene. Despite how they met, Sonny and Sam soon became lovers, and it wasn't long before Sam became pregnant. Then Sonny reunited with his wife Carly and his closest friend and employee, Jason Morgan, claimed that the baby was his. Jax also wondered if he was the child's father but the truth regarding the child's paternity was revealed soon after.
Sam eagerly awaited the birth of her child, but was soon dealing with another secret -- years before, she had sought out her mother, who had wanted nothing to do with her, and her mother had died in a fire. Her stepfather, Stuart Mest, had implicated Sam in Evelyn's death, but the truth was that Danny, Sam's mentally challenged half-brother, whom Stuart and Evelyn had kept a virtual prisoner, was the one who had really set the fire. Sam was cleared and looked forward to raising her child, but then Sonny's young daughter with Alexis Davis, got sick. Sonny's daughter Kristina needed the stem cells from Sam's baby's umbilical cord, since no one in the families was a match. Although Sam was reluctant to risk the baby's life, she agreed to have labor induced, but tragedy struck and the baby died at birth. However, the stem cells were still viable and Kristina made a full recovery.
Sam grew closer to Jason after the death of the baby, whom she named Lila in honor of Lila Quartermaine, and the two made plans to adopt "Hope," the infant daughter of a teenager. In the end, the birth mother changed her mind regarding the adoption and blamed Jason for losing their chance to be a family. Sam swore she would never forgive Jason and began moving away from him, and was even suspected of having kidnapped Sonny's three children. She and Jason were able to move forward as they paired up to bring the children home. Sonny was grateful for their role in bringing his children home and sent Sam and Jason on a vacation.
Sam and Jason didn't get much chance to enjoy their vacation because they were kidnapped by a woman named Allegra. She needed Sam to impersonate her dead daughter, Alicia, and marry Alicia's fiancé, Andrew, so that Allegra could replenish the family coffers. Sam agreed, because Allegra was holding Jason hostage in her cellar, but soon learned that Alicia, a dead ringer for her, was alive and well. Sam married Andrew, but confessed the truth to him. She and Andrew made their way back to the mansion, but Sam later found a dead Andrew next to an unconscious Jason.
Sam was arrested and charged with Andrew's murder, but Allegra showed she had a heart, after all, when she arranged to free Sam, and had her own daughter, who was the real killer, imprisoned in Sam's place. Jason disappeared after suffering another seizure and losing his memory altogether. When he arrived back in Port Charles, Sam learned the severity of his condition but refused to accept that he was going to die. Sam called Jason's old girlfriend, Robin Scorpio, who had become a specialist in brain disorders. Although her treatment was not successful in curing Jason on its own, the surgery Jason restored Jason's memory. Their happiness was tempered by the arrival of a man named Manny Ruiz. He threatened Sam and broke into her apartment several times.
Sam's fear of Manny was overtaken by another fear after both she and her brother Danny became ill when an encephalitis plague hit the city. Sam received the serum and survived, but Alexis Davis received the other available dose. Sam asked Alexis to give the serum to her brother and reminded Alexis of the stem cells Kristina had received courtesy of Sam's deceased child. Alexis was unable to grant Sam's request and Danny died. Just before Danny passed away, he told Sam how their parents had "chosen" her. A DNA test confirmed that Sam and Danny were not biologically related.
Sam was devastated to realize she had been adopted and had never known it. Initially, Sam was hesitant to find her mother, but in the end, her desire to know was stronger than her fear of rejection. Her search led her to discover that her mother was none other than Alexis Davis, who had been forced by her father, Mikkos, to give up her baby for adoption. At first, Sam wanted nothing to do with Alexis. There was too much hurt and resentment between the women, and it didn't help that Alexis viewed Sam's relationship with Jason as unhealthy and bordering on abusive.
Alexis had good reason to be concerned about Sam's well-being with Jason. Manny continued to stalk Sam and embarked on a crime spree, killing several Port Charles residents. One night, while Sam was happily running into Jason's arms, Manny shot her. Sam was gravely wounded and rushed to General Hospital. Worried that the worst could happen, Jason decided to tell Alexis that Sam was the daughter she'd given up at birth. Alexis was stunned and became very protective of Sam.
When Jason blamed himself for Sam's shooting, feeling as if his lifestyle had put Sam in the line of fire, Alexis didn't argue. She agreed and pushed him to walk away from Sam so that Sam could have a chance at a long and happy life without all the violence and death. When Sam woke up, she was devastated to hear Jason break things off with her. She grew to resent Alexis for her role in the breakup but ultimately accepted Alexis' offer to move in and recuperate. Sam was torn between bonding with her new family and despising her mother for costing her the love of her life.
Confused, hurt, and frustrated over Jason's continual refusal to reconsider things, Sam started nurturing a friendship with her mother's husband and Jason's enemy, Ric Lansing. Ric and Alexis were having difficulty. Ric felt Alexis was being distant and cold toward him. Sam didn't care much for Ric, but she knew that Alexis did. Wanting to hurt both Alexis and Jason as they had hurt her, Sam started down a path she couldn't turn away from. Sam pleaded with Jason to give their relationship one more chance but he pushed her away. When she returned home, she engaged in a heated argument with Alexis.
After Alexis stormed out, Sam and Ric nursed their hurt with some alcohol. Before long, they were having sex on the living room floor. They did not realize that Alexis would return a short while later and see what was going on in her living room through the window. Nor did they realize that Jason had stopped by to talk to Sam in the hopes of reconciling, and he saw her on the floor of the living room with Ric. Sam went to see Jason the next day with plans to confess what she had done with Ric. She learned that not only had Jason seen with his own eyes what had happened but that he had turned to Elizabeth Webber and spent the night with her in his penthouse. Sam was hurt but realized she had no room to judge him.
They decided to move slowly and rebuild their relationship but hit several stumbling blocks. The first was when Alexis revealed that she was suffering from stage three lung cancer and needed surgery. The next was Sam's arrest for a stolen flashcard. Ric had framed Sam in the hopes of using her to get to Jason. He showed Sam some surveillance pictures of Jason and Elizabeth, spinning it to prey on Sam's insecurities. In a panic, Sam fled custody and went on the run.
Jason soon caught up to Sam and helped her escape. Unfortunately, others caught up, as well, including Diego Alcazar. In an exchange of gunfire, Sam managed to kill Diego before he killed her, Jason, and Spinelli. Unfortunately, her little sister Kristina happened along and witnessed the violent crime. Before long, Jason and Sam were able to clear her name, and Sam tried helping her sister, who was in a catatonic state as a result of witnessing the shooting.
When things started settling down, Sam's desire to be a mother grew stronger. She'd never quite stopped wanting to start a family, but it seemed that the timing was always off. Certain that the time was right, Sam brought up the idea to Jason. She was surprised at his reluctance and somewhat hurt. Months earlier, Elizabeth had learned she was pregnant and there was a possibility that Jason could be the father. He'd offered to marry Elizabeth, but she had turned him down. Sam couldn't understand why Jason didn't seem to have a problem with having a child with Elizabeth but was reluctant to have one with the woman he claimed to love. Jason explained that the difference was in Elizabeth's case the baby had already been conceived. Jason just didn't feel it was right to plan to bring a child into his violent lifestyle.
With time, Sam convinced Jason to trust that they would protect their child. Unfortunately, by that time, Sam had received some heartbreaking news. Her uterus had been severely damaged when she was shot the year before. There was extensive scar tissue that would make conceiving or carrying a child full-term impossible. Sam was crushed and needed time to come to terms with it before telling Jason. Before she had a chance to share the devastating news with Jason, gunmen seized the Metro Court hotel. Sam was working behind the reservation desk when it happened. She hit the silent alarm, which also triggered the vault to lock for 15 hours.
As the police surrounded the hotel, the gunmen terrorized the hostages. The leader was infuriated because what he wanted was inside the vault. Eventually Sam managed to escape and warn the police about what to expect inside. Moments later, the police stormed the lobby of the hotel just as it exploded. As a result of Sam's actions, a television producer courted her to host a new show called Everyday Heroes. Sam was flattered but initially reluctant. Amelia Joffee was persistent and finally convinced Sam to give it a try. What Sam didn't realize was that Amelia was the daughter of Bill Monroe, one of the five men she had married under various aliases and stolen fortunes from.
Amelia was out for revenge. She was convinced that Sam, at the time using the name Angela Monroe, had murdered Bill when he'd realized that she was about to steal his fortune. The truth was that Sam had killed Bill Monroe in self-defense. Sam, using the alias Angela, had been arrested and tried for the crime, but in the end had been acquitted. Amelia was not satisfied with the verdict and intended to expose Sam for the fraud that she was.
As Sam's career flourished, her personal life fell apart. Sam was told that her eggs were not viable so she would never have a biological child. She was desperate to keep Jason from learning about her past and she started lying about various incidents. As time passed, they grew distant. Then one day Sam overheard a conversation between Jason and Elizabeth in which Sam learned that Jason was the biological father of Elizabeth's son Jake. The discovery shattered her.
Weeks later, Jake was kidnapped. By that time, Jason had been arrested for Lorenzo Alcazar's murder. Sam and Jason were barely speaking. Sensing she was losing Jason to Elizabeth, Sam hit rock bottom. She had interviewed a distraught mother that had recently lost her daughter in a fire. Sam watched the mother take Jake out of his stroller while Elizabeth had her back turned but Sam did nothing. She watched and returned to the studio. When the police questioned her about being in the park just before Jake's kidnapping, Sam lied and said she'd seen nothing. Her conscience, however, plagued her. Sam started drinking and ended up on Elizabeth's doorstep, trying to console the grieving mother. It was a disastrous decision.
Sam's behavior raised questions, and Amelia started suspecting Sam of kidnapping the infant herself. She went to Jason with what information she had on Sam, including all of her aliases and the marriage scams. Jason defended Sam but he wondered why she had hidden information from him regarding her past.
Around the same time, Jason was released on bail. Amelia called him with a possible lead on Jake, and they found the baby. Jason was overjoyed to be reunited with his son. His joy soon turned to confusion when the woman jumped to the conclusion that Sam had told Jason where he could find Jake. He learned that Sam had seen Jake being kidnapped. Jason returned Jake to Elizabeth's waiting arms, but before he could talk to Sam, he was arrested for jumping bail then shipped off to the state penitentiary to await trial.
Sam paid Jason a visit and discovered that he knew her role in Jake's kidnapping. She admitted to everything and let him see her anger. Jason didn't hold back. They traded angry words before Sam ended things and walked out. Things remained tense between them through the trial. Jason worried that Sam would be out for revenge and would deliberately incriminate him in Lorenzo's death. She didn't. In the end, Sam's testimony helped, rather than hurt, Jason's case. During the trial, Elizabeth's night with Jason was revealed but they continued to lie to Elizabeth's husband Lucky and allowed him to believe that he was Jake's father.
Sam was blinded by her own pain and focused all of her anger on Elizabeth. Determined to make sure Elizabeth had nothing, Sam hired armed goons to terrorize Elizabeth and the children in the park. She wanted the goons to pretend to kidnap Elizabeth and the children before Sam made a timely arrival and chased them away. Sam's intention was to remind Elizabeth that Jason's enemies lurked everywhere. Her plan worked too well. Jason, worried about the threat to Elizabeth and the children, started hunting down the men. With Spinelli's help, Jason was able to trace them back to Sam. Realizing the danger Sam had put Elizabeth and the children in, Jason confronted Sam. He threatened to kill her if she ever hurt Elizabeth and the boys again.
Sam couldn't believe that Jason would go that far. Then he issued the threat again. Sam blamed Elizabeth and was determined more than ever to ruin Elizabeth's life. Sam set out to seduce Lucky and quickly had him in her bed. The Spencer marriage fell apart, and Sam found herself drawn to Lucky more than ever. It bothered her how Lucky continued to think the best of Elizabeth, knowing she continued to lie about Jake's paternity. That resentment grew until finally Sam forced the truth out of Jason and Elizabeth.
Lucky was stunned and dropped out of sight to absorb everything he had learned, including the realization that Sam had known the truth for quite some time without telling him. When Lucky came around, he had a long talk with Sam. He told her that he intended to continue raising Jake as his own son, but he needed to know that Sam would leave Elizabeth alone for the children's sake. Sam agreed, but the damage had been done. Lucky learned of Sam's role in Jake's kidnapping and the stunt she had arranged with the gunmen in the park. Lucky claimed he could not trust her and threw her out of his home.
Brokenhearted, Sam ended up on the docks and was attacked by the Text Message Killer. She managed to escape him but wound up being run down by a car. Luckily, her injuries weren't fatal. She was released from the hospital and went home, where the Text Message Killer was waiting for her. Sam was stunned to discover that the Text Message Killer was none other than Diego Alcazar, the man she thought she'd killed a couple of years earlier. Diego had survived the shooting and was targeting the women close to Sonny and Jason so that they would have a taste of the loss he had experienced when they ordered his father, Lorenzo Alcazar, killed.
Lucky and Sam, reconciled and they worked together to investigate counterfeit medication that was showing up in Port Charles. Sam and Lucky thought either Dr. Ian Devlin or Jerry Jacks could be connected to the counterfeit medication. Against Lucky's wishes, Sam went undercover and took a job landing shipments for Andrei Karpov, a Russian mobster who was smuggling drugs into Port Charles. Karpov no longer trusted Sam after the police intercepted one of Karpov's shipments.
Lucky was disappointed with Sam's decision to continue to investigate the counterfeit medications due to the danger the investigation posed. Sam planned to flirt with Jerry Jacks to obtain proof Jerry was smuggling drugs with Karpov. Sam tried to seduce Jerry in her hot tub and then steal his PDA, but Jerry was one step ahead of Sam. He planted evidence in Sam's apartment, and she was arrested for possession of illegal drugs.
Nikolas Cassadine bailed out Sam on Lucky's behalf. Sam confessed to Lucky that she would have slept with Jerry to obtain evidence, so Lucky left town to think about their relationship. When Sam was released from jail, Jerry kidnapped and imprisoned her on a boat. Jerry also strapped a bomb to her. Jason worked with Spinelli to rescue Sam. When Lucky returned to town, he was grateful Sam had survived. He forgave Sam for placing herself in danger once again.
Sonny killed Karpov, and Karpov's associates targeted everyone close to Jason and Sonny, which included Sam and Elizabeth. Jason arranged for Sam to take Liz and her boys into hiding at a cabin in the woods. The Russian mobsters found Sam and Liz and tried to enter the cabin. Sam and Liz engaged in a shootout with the Russians. During the fight, Karpov's associates kidnapped Jake. Sam and Jason found Jake at a different cabin, which had been rigged with explosives. Sam saved Jake's life when the cabin exploded. One final associate of Karpov's named Sasha, remained in Port Charles. Sasha and Sam had an altercation, and Sam fell into a mineshaft. Sam injured her hip in the fall and was unable to climb out. Sasha was killed before she could reveal Sam's whereabouts, but Jason rescued Sam.
Lucky was frustrated with Sam's addiction to danger, and he was disappointed when Sam decided to become a private investigator. Sam and Lucky ended their relationship as friends when Lucky realized he still loved Elizabeth. Spinelli went into business with Sam, and they named their firm McCall and Jackal Private Investigations.
Jason hired Sam and Spinelli to determine who had shot Sonny's son Michael. Jason suspected Jerry Jacks was involved. Sam and Jason ran into Jerry when they traveled to Mexico to take Sonny's children, Michael and Kristina, home. The children had run away to Mexico when Kristina caused a car accident that had resulted in Sonny's pregnant wife, Claudia Zacchara, losing her baby. Jerry had made contact with Michael and Kristina because he knew Jason would show up wherever Michael was.
Jason was severely injured when Jerry shot him twice and a roof collapsed on him. Sam stayed in Mexico and took care of Jason. Sam and Jason became lovers again and they professed their love for one another. When they returned to Port Charles, Sam and Jason uncovered evidence that proved Claudia Zacchara, Dr. Ian Devlin, and Jerry had been behind Michael's shooting.
A mysterious artist called Franco began to cause trouble in Port Charles. Franco was obsessed with Jason. Franco kidnapped Sam and tied a bomb to her, and he planned to kidnap Carly also. Franco wanted to force Jason to choose one woman to save: Carly or Sam. When Franco was unable to kidnap Carly, he kidnapped Lulu Spencer instead. Sam and Lulu were each tied to a bomb, but they were on opposite sides of town. Jason saved Sam while Lulu's boyfriend Dominic, who was later revealed to be Dante Falconeri, a detective, saved her.
Sam helped Jason, Sonny, and Carly cover up Michael's involvement in the death of Claudia Zacchara. Claudia had kidnapped Carly as had gone into labor. Carly had delivered the baby in a deserted cabin, and Claudia had planned to steal the baby. Michael had found the cabin first and had killed Claudia to protect Carly and the baby. Sam and Jason had arrived shortly after. Sam had taken Carly and the baby to the hospital while Jason had dealt with Michael and with Claudia's body.
Eventually, the truth about Claudia's murder was revealed, and Michael was sent to prison. Jason made arrangements to join Michael in prison so he could protect him. Sam was heartbroken, but she supported Jason's decision. Sam and Jason considered getting married so they could have conjugal visits, but they decided against it. While Jason was in prison, Sam looked for information she could use to blackmail the judge that had sentenced Michael, so the judge would release Michael and Jason. Sam was able to stop her investigating when both Michael and Jason were released from prison, courtesy of Detective Dante Falconeri.
Sam was a supportive sister when Kristina's boyfriend, Kiefer Bauer, abused her. Kristina originally named Ethan Lovett as her abuser, which prompted Sam to attack Ethan. When Kristina later revealed it was her boyfriend, Kiefer, that had abused her, Sam stood by Kristina and helped Kristina move past the abuse. Sam also helped Alexis decide how to proceed when Kiefer died as a result of being hit by a car Alexis was driving. Alexis confessed and was able to avoid jail time.
When Jason's ex-wife, Brenda Barrett returned to Port Charles and moved into Jason's penthouse, Sam tried to give Jason space. Brenda needed protection from a European mobster named the Balkan. Jason asked Sam to investigate the Balkan, but Jason refused to share Brenda's secrets. Sam explained to Jason that she would understand if Jason wanted to rekindle his relationship with his ex-wife. Jason assured Sam he had never loved Brenda and never could because Sam had his heart.
In January 2011, Sam learned she might be able to have a child. Sam was a candidate for fertility reconstructive surgery. She and Jason went back and forth on whether or not they should be parents. They had already accepted a life without children.
The discussions about a baby were put on hold when Sam's sister Molly overheard an attorney named Theo Hoffman confess to being the Balkan. Sam and Jason went after the Balkan, and the Balkan kidnapped Sam. She was placed in the back of Sonny's limousine, which exploded. Since Sonny's limousine was bomb-proof, Sam emerged with a concussion, a few scrapes, and temporary hearing loss.
When Sam was released from the hospital, she got a lead on the location of one of Theo Hoffman's men. As Sam drove to investigate the lead, she suffered a severe headache while driving. Around the same time, Jason and Elizabeth's son Jake was hit by a car and killed. Sam thought she could be the one that hit Jake. DNA evidence cleared Sam, but revealed Luke Spencer was the driver.
Jason decided he was ready to be a father soon after Jake's death, so Sam underwent the fertility reconstruction. Shortly after the conversations about having a child, Jason questioned Sam about her feelings on marriage. She insisted she was happy with their relationship the way that it was and did not need a piece of paper to confirm those feelings. Sam suspected marriage was on Jason's mind and she discussed the possibility of marrying Jason with her mother. Alexis surprised Sam by giving her blessing. Sam was surprised again when she met Jason for a rooftop picnic and he proposed. Maxie had lost the ring Jason picked out for Sam but she accepted a metal lug nut instead and accepted the proposal.
Sam and Jason slowly shared the news of their engagement. Carly did not take the news of their engagement well and they tried to set boundaries with her. Carly was offended but she showed up again soon after and claimed she needed Jason's help because Jax had sneaked back into town to take her daughter Josslyn. Sam begged Jason not to go but he went along with Carly. Shortly after Carly and Jason took off, they were involved in a car accident and Jason was rendered unconscious. Sam blamed Carly for the accident and the head trauma Jason suffered and accused her of being selfish.
Jason underwent surgery and while he recovered, Sam's sisters and Maxie continue to plan the wedding, although several disasters occurred during the planning process and Maxie declared the wedding jinxed. Regardless, when Jason left the hospital, he and Sam remained on course to marry. Sam started to believe her wedding was doomed when Jason walked in and saw her trying on her wedding dress. She was overwhelmed until Jason took her on a motorcycle ride and they ended up at a Chinese restaurant. They lamented their wedding woes to the elderly couple that ran the restaurant and explained that they simply wanted to be married without all the fuss. The elderly couple's grandson shared that he was an ordained minister and he performed the ceremony on the back terrace of the restaurant. Sam and Jason exchanged rings that had once belonged to Jason's grandmother and his father.
On the day of the planned wedding, Sam and Jason showed up for their wedding together in casual clothes and announced they were already married. They returned back to the Chinese restaurant where they were married and held an informal reception with their friends and family. After the celebration, the newlyweds honeymooned in Hawaii and enjoyed a romantic time together until Carly, her daughter Josslyn, and her bodyguard Shawn showed up. Carly and Shawn claimed Franco had made contact with them and they suspected he was in Hawaii.
Jason searched for evidence that Franco was near until he received word Franco had been spotted far away from Hawaii. Carly, Josslyn, and Shawn returned to Port Charles while Sam and Jason stayed to enjoy the final days of their honeymoon. Sam and Jason were unaware that Franco had cameras set up and had watched them. While Jason and Sam were out planning romantic surprises for one another, Franco interfered with their plans. He drugged Sam and made it appear that he raped her while Jason was locked in a room and forced to watch.
When Sam recovered, she was confused by what had happened and could not remember seeing Franco. Jason told her what he had witnessed and he vowed to kill Franco for hurting Sam and blamed himself for not being able to protect her. Sam reminded Jason that what Franco had done to her was not his fault, although their relationship was strained as they ended their honeymoon and headed back to Port Charles. Franco also made his presence known in Port Charles and left graffiti tags around town with a message that referenced creation.
Sam understood Franco's message when she discovered she was pregnant by either Franco or Jason. She and Jason decided to have a paternity test run before they made the news of the pregnancy public and they were relieved to learn that Jason was the unborn child's father. Before they were able to fully celebrate the news, Jason suffered a health crisis and was admitted to the hospital where they learned he had inoperable brain swelling. His best hope for survival was for Robin to develop a drug therapy that Patrick could implant into his brain. Robin worked to create a miracle for Jason and she was killed when a fire broke out in her lab.
In the aftermath of Robin's death, Sam had to ask Patrick to do the impossible and proceed with the drug protocol Robin had given him before she died. In his grief over the loss of his wife, Patrick initially refused and blamed Jason for being the reason Robin had been killed. Sam begged Patrick to save Jason and shared with him that she was pregnant and did not want her child to miss the chance to know his or her father.
Patrick did agree to do the surgery and he expected Jason to make a full recovery. While Jason remained hospitalized after the surgery, Sam barred Carly from visiting Jason. She also made sure that all of Jason's visitors did not share the news of Robin's death. Sam decided that it would be best for Jason to hear the news after he had made a full recovery. Jason asked repeatedly to see Robin but each time Sam made an excuse.
Despite Sam's efforts to keep Carly away from Jason, she sneaked in and told him about Robin's death. Jason was furious that Sam had lied to him and made decisions for him. He took off from the hospital and went to the church were Robin's funeral had been held earlier in the day. Sam tracked Jason down and they had a heated argument. Jason took off while Sam remained at the church. A man named John McBain entered and although he was a stranger, Sam felt a connection to him and she shared her troubles with him. She regretted telling him about her marriage when she later learned that John was a police officer from Llanview Pennsylvania and he was in Port Charles to investigate Sonny's role in a car accident that had killed two citizens from Llanview.
Jason forgave Sam's decision to keep Robin's death a secret and he asked Sam to stay away from John. Both Jason and Sam were concerned about a video that had received while Jason was in the hospital. The video showed footage of Jason as a newborn and they believed it was a clue from Franco. Sam took a trip to New York and went to the hospital where Jason had been born to search for more information. When Sam looked at the hospital records for Susan Moore, Jason's birth mother, she realized that a portion of the records were missing. Sam realized that Susan's cousin Heather Webber had been present at the birth and paid Heather a visit at Ferncliff, the mental institution in which Heather resided.
Sam was shocked when Heather revealed that Susan had passed out after giving birth to Jason and was unaware that she had been pregnant with twins. While Susan remained unconscious, she delivered a second son that was Jason's fraternal twin. Heather gave the second baby to the nurse in exchange for the payment of Susan's medical bills. Susan was never aware that she had more than one baby. Heather told Sam that the nurse that had adopted the second baby was named Elizabeth Frank, although she went by Betsy. Sam immediately recognized the name, as Betsy Frank was Franco's mother.
The obsession Franco had with Jason was suddenly clear and Sam was horrified to realize that Franco and Jason shared DNA so the results of her original paternity test were moot. Sam struggled with what to do and she confided in John instead of Jason. She told him about Franco's involvement in their lives and her rape. John encouraged Sam to tell Jason everything that she had learned but Sam insisted she wanted to wait until she knew for sure who the father of her baby was. John informed her that would get her a sample of Franco's DNA from the FBI files so a more conclusive test could be run. Sam thanked John and she made arrangements to have another DNA test conducted without Jason's knowledge.
Although Jason was unaware of the new paternity test, Heather Webber learned of the test and threatened to tell Jason. Sam reminded Heather that she would be glad to tell Heather's son Steven about how she had sold Franco at birth.
When the results of the test came back, Sam was devastated to learn that Franco, not Jason, was the father of her child. She shared all the devastating news with Jason regarding his connection to Franco and the paternity of the baby. Jason was angry that Sam had not confided in him but instead had turned to John. When Sam pressed Jason to address the issue of her baby, he admitted that he could not commit to raising the child as his own and Sam moved out.
Sam moved in to the Rendezvous motel, which happened to be the same motel John was staying at. Unbeknownst to both of them, Ronnie Dimestico was also there but he was not alone. Ronnie had kidnapped Lulu Spencer and Sam accidentally discovered them. He took Sam hostage as well but the women worked together and convinced Ronnie to take them to the deserted Haunted Star casino. They left clues to their whereabouts which John and Lulu's husband Dante used to find them. Dante distracted Ronnie so Lulu was able to escape but Ronnie held on to Sam and threatened her and her unborn child. John intervened and killed Ronnie in order to save Sam.
After the ordeal, Sam and Jason continued to drift apart. Jason spoke to Elizabeth about his marriage while Sam continued to spend time with John. Eventually Molly and Alexis learned that Sam had moved out and she shared the truth about her marriage and how her baby was conceived by rape. Her family offered their love and support and Molly stepped in as Sam's birthing coach in Jason's absence.
Sam continued to reside at the motel and she was there with John on a stormy night when her water broke. The phone lines were down due to the storm and John helped Sam deliver her son in the motel room. Afterward, John left Sam and her son so he could get a car to transport them to the hospital but he never returned. Sam was concerned about her son's breathing so she took off with him on foot to find help.
Sam saw a road closed sign and headed toward a light in the woods that came from a small cabin. She placed her son outside the cabin while she went inside to seek help. As she entered the cabin, she passed out. When she awoke, Jason was by her side and she inquired about her son. He told her that her son had died but she demanded to see him. Jason placed the baby in her arms but she declared that the baby was not the child she had given birth to.
Jason took Sam and the baby to the hospital and an autopsy was ordered. As they awaited the results, Sam questioned why she had to endure the pain of losing another child and wondered if her son would have survived if John had returned to help her. The autopsy revealed that the baby had hemophilia although that had not shown up in any of the tests during the pregnancy but the cause of death was respiratory failure. Sam continued to wonder if her child might have survived if she had gotten her son to the hospital sooner.
Sam wanted to blame John for her child's death until she learned that he had not returned to help her because he had been severely beaten on his way to get the car. The men that had attacked him had been ordered to do so by Jason. She sent Jason away and refused to forgive him for what he had set in motion.
After the loss of her child, Sam returned to work and joined Spinelli on his current case which involved an investigation of Heather. Sam told Spinelli about the grudge Heather held against her and admitted that she would love to find evidence that would send Heather back to Ferncliff. Spinelli and Sam realized that Heather and Todd Manning shared some sort of connection so Sam went undercover as Todd's assistant at Manning Enterprises.
Although Sam tried to focus on work, she contemplated the future of her marriage and she continued to confide in John while Jason leaned on Elizabeth. On the Fourth of July, San and John comforted one another and shared a kiss, unaware that Jason had witnessed it. Jason responded by kissing Elizabeth. Although she still loved her husband, she was unable to forgive his role in what had happened to her baby.
Sam moved forward with her investigation into the connection between Heather and her boss and suspected that the secret they shared involved her child. She was fired after Todd caught her breaking into his safe and forced to examine her feelings for John when her mother represented him. Sam admitted to Alexis that she felt something for John but remained in love with Jason.
Jason and Sam tried to work out their feelings for one another but the couple decided to file for divorce after they were unable to reconcile their differences. Jason was not willing to accept Sam's friendship with John and she continued to blame him for her son's death. Sam wondered if she and Jason still had a chance at happiness after the spent what they believed were some of their final moments together when they were both sickened with a deadly toxin that Jerry Jacks had placed in the water supply. Sam and Jason both survived and Sam tried one last time to save her marriage. She decided to move forward with the divorce after Elizabeth falsely led her to believe that Jason had moved on.
Sam sensed that Jason was keeping something from her and she assumed it was his relationship with Elizabeth. He was actually following up on the possibility that her son was still alive. Jason, along with John and Spinelli, confirmed that Sam's living son had been switched at birth with Téa Delgado's deceased child. Jason theorized that Heather and Todd had made the switch while Sam had been unconscious after giving birth. Jason shared the joyous news with Sam but her joy was tempered when she learned that Heather had kidnapped her son.
Together Jason and Sam rescued the baby from Heather and Sam named her child Daniel Edward Morgan. She decided to move back in with Jason as his wife and they planned to raise Danny together. On their first night home as a family, Jason was called to the docks for a meeting with his accountant. He was shot and fell into the harbor. Although his body was not recovered, he was presumed deceased. Sam refused to give up on Jason and continued to search for him. As she dealt with Jason's absence, she learned that Heather had altered her paternity test and that Jason was her son's father.
As time passed, Sam was forced to accept that Jason was gone. She spent time with her family and helped care for John after Lucy Coe accused him of being a vampire and stabbed him. Lucy insisted that John was a vampire named Caleb Morley and that Sam was actually Livvie Locke, the target of Caleb's obsession. Both Sam and John assumed that Lucy was mentally unstable and dismissed her rants until John was accused of several crimes, including two murders.
In the meantime, Heather Webber escaped once again from Ferncliff and kidnapped Danny. After Heather took Danny, John's doppelganger Caleb took the child but Todd Manning managed to rescue him. Once Sam was reunited with her son, Caleb reappeared and kidnapped both of them and took them to Spoon Island. Caleb insisted that Sam was his wife Livvie and claimed that she would remember their life together after her bit her three times. He managed to bit her twice before John and Lucy rescued her and Danny. Caleb, who was actually a psychiatric patient named Stephen Clay, was killed during the rescue.
After Sam recovered from her experience with Steven Clay, she was granted temporary legal guardianship of Steven's son, Rafe Kovich, Jr. The teen's mother had been murdered recently by Steven, his father, in front of him. Rafe had also been kidnapped by Steven but had helped to protect Danny during the ordeal. Rafe's addition to Sam's home helped to distract her from grief over Jason and the loss of her friendship with John after his FBI required departure from Port Charles.
Sam feared that Rafe would also be removed from her life after she ran into a man that she mistook for Steven Clay. After an uncomfortable introduction, Sam learned the man was Steven's brother, Doctor Silas Clay. Silas was unaware of his brother's death or that he had a nephew. Silas demanded custody of nephew despite Rafe's discomfort with the physical similarities between Silas and Steven. Sam lost the legal battle for guardianship of Rafe but Silas allowed Rafe to remain in her home after Silas diagnosed Danny with leukemia.
Silas developed a personal interest in Danny's case and took over as the head of oncology at General Hospital. Sam was not pleased with the bedside manner Silas displayed but she believed he could provide the best treatment for her son. She was distraught when Silas informed her that Danny's survival was dependent upon a bone marrow transplant. During this time, Franco was revealed to be alive and claimed that he was a changed man. Franco experienced a seizure and afterwards believed that he was Jason. Franco took Danny out of the hospital and brought him to the penthouse. When Sam arrived, Franco would not allow her to see her son a struggle ensued between them. During the altercation, Sam was rendered unconscious. Shortly after Sam regained consciousness, Franco was found with Danny and she learned that Franco was a bone marrow match for her son.
However, due to other health concerns, Franco was not eligible to donate his bone marrow and the donor search continued. A businessman new to Port Charles named Derek Wells was able to save Danny's life. When Danny's health crisis was over, Silas and Sam admitted that they shared a mutual attraction and decided to explore what could be between them. Meanwhile, Derek was revealed to be Julian Jerome, a member of an organized crime family and Sam's biological father. Sam shunned her father after he used Danny's illness and the potential that it could return as a way to safeguard his life from his mob rival Sonny.
Around the same time, a police detective named Nathan West arrived in town and accused Sam of being involved with a married man that was accused of attempted murder. Sam was shocked by the accusations about Silas but chose to believe him when he explained that his wife Nina had been in a coma for over twenty years after she was given an overdose of medication. With Sam's help, Silas was cleared of any wrongdoing. In return, Silas supported Sam's decision to allow Julian to be a part of her life. Julian stepped into the role of overprotective father after Silas' wife Nina was revealed to be alive. Silas swore that he loved Sam and insisted that Nina's return did not change their relationship. Sam hoped that Silas was correct.
Although Sam and Silas had declared their love for one another, it was not enough to save their relationship. When Rafe was revealed to have been the driver that caused the death of Patrick Drake's infant son, Sam believed that Rafe's death on Patrick's operating table had not been intentional but Silas disagreed. She explained to Silas why she thought Patrick was innocent and was furious when their private conversation was leaked to the press and resulted in Patrick's termination from the hospital. Sam theorized that Nina had eavesdropped and shared the information in hopes of driving a wedge between Silas and Sam.
When Silas refused to consider that Nina had an ulterior motive, Sam ended their relationship. She grew closer to Patrick as they worked together to investigate his car accident. Patrick and Sam shared a mutual attraction which led to a kiss but Sam decided that she needed time to heal after her break-up before she pursued a new relationship. Her decision was reinforced after she learned that Patrick had known that Jason had been alive and receiving medical treatment from Robin at the Crichton-Clark clinic. Although Robin's attempt to save Jason had failed, Sam felt betrayed by Patrick's choice to keep information about Jason from her.
Sam reconsidered Patrick's place in her life and they became lovers. She also worked to uncover the identity of the man that had held her at gunpoint and helped Cesar Faison escape police custody. She suspected that Elizabeth's new housemate, an amnesia patient named Jake Doe, was the culprit. Eventually Sam found a link between Jake and a break-in that occurred at her home. When she pressed Jake, he was able to remember that he had been ordered to kill her and that had been the one to take her hostage. When Jake's actions were revealed to be the result of a microchip implanted in his brain curtesy of Helena Cassadine, Sam forgave him and hoped that Jake could remember his identity.