Alexis originally arrived in Port Charles in 1996 to defend Kevin Collins for stalking Felicia Jones. She then defended Monica Quartermaine in the sexual harassment case that Dr. Dorman brought against her.
Perceiving Katherine Bell and her relationship with Stefan as a threat to her family, Alexis worked to convince Stefan that Katherine was his half-sister, Natasha, who had been believed to be dead. However, Stefan discovered her plan and wanted nothing more to do with her. To make matters worse, she then found out that she was the real Natasha.
Helena had murdered Alexis' mother, and threatened Alexis with the same fate should she not do Helena's bidding. Helena forced her to defend Tony Jones for kidnapping, which cost Alexis her relationship with Ned Ashton as well as her job at ELQ.
Desperate to get rid of Helena, Alexis teamed up with Luke Spencer and the two devised a plan to murder her. They set a trap for Helena, but Katherine Bell ended up stepping into it, and fell to her "death." Alexis defended Stefan when he was accused of killing Katherine, and the fact that she was his sister, not his cousin, was brought to light. Alexis then told Ned who she was and why she defended Tony, and Ned was upset that Alexis had not come to him with the truth sooner, but he understood and the two began to see each other again.
When Alexis learned that Nikolas was not the prince, she felt betrayed that Stefan had kept the truth from her for so long. With the Cassadine fortune up for grabs, Alexis decided to go after it with the help of Jasper "Jax" Jacks. But when she almost ended up dying in a plane crash that Helena caused, she decided that the risk was not worth it. She then decided to concentrate on building a life away from the Cassadines by focusing of her profession and her relationship with Ned.
When Chloe Morgan appeared in town, she immediately became friends with Alexis and Ned, as well as Jax. So when Chloe was in danger of losing her company if she did not get married within the next month, her new friends stepped in to help. Ned and Alexis decided that the best solution would be for Chloe to marry Ned. After much deliberation, Chloe decided to go along with the plan. Alexis, Ned, Chloe, and Jax flew to Las Vegas, the perfect place for a quick marriage. The only problem was that Chloe's Aunt Gertrude showed up, and claimed that the Vegas wedding did not comply with the legal definition of "happily married" as it was stated in the will.
In order to cover up the real plan, Jax and Alexis got married instead. To make it appear that Ned and Chloe's impending marriage was real, Jax and Alexis needed to make it appear as though their marriage was also real. They even went so far as to move Alexis into Jax's penthouse. Jax and Alexis became good friends while married, as did Ned and Chloe. The four finally divorced when Chloe's Aunt Gertrude caught Chloe and Jax together, which allowed her to take the company. Alexis immediately, at Ned's request, moved the elegant promise ring he had given her from her right hand to her left, which made them officially engaged.
With Ned and Alexis happily and publicly together again, Ned decided to restart his music career as Eddie Maine. One night while on tour in Detroit, Ned returned to his hotel room with an interviewer and camera crew doing a story on "A Day in the Life of Eddie Maine." All was going well, that is until Ned opened the door to find Alexis waiting on the bed for him wearing nothing but a teddy and holding a rose in her teeth. Affectionately nicknamed "Eddie's Angel," Alexis could do nothing to escape the press, fan letters, Internet sites, and emails. Attempting to end the fiasco, Ned proposed to Alexis because he thought that if they were married, the press would leave them alone. Unfortunately, he was proved wrong when their private wedding in Belize was discovered.
Ned then decided that the best way to get rid of the press was to give them exactly what they wanted, a publicized wedding. After reluctantly agreeing, Alexis and wedding planner Elton arranged a big public wedding, complete with press. After many obstacles, they finally made it to the wedding day. As Nikolas escorted her down the aisle, Alexis began to have nightmares about becoming a Quartermaine wife, and fled. Meanwhile, when Stefan returned home after faking his own death, Nikolas wanted nothing more to do with him and shut him out. He was furious about being lied to, and, instead of having Stefan take over as trustee of the Cassadine holdings, Nikolas gave Alexis the job.
When Ned's cousin, Emily Quartermaine became involved with Zander Smith, she arranged for Alexis to be Zander's lawyer, as he was in a lot of trouble with the law and mob boss, Joseph Sorel. Also, in exchange for his testimony against Sorel, Alexis' client, mob boss Sonny Corinthos, would give him protection in the event that Sorel tried to kill him. Sonny also agreed to post Zander's bail of two million dollars. On the night that Zander was released from jail, Emily, Zander, Alexis, and Sonny were walking down the steps of the Port Charles Police Station, when two gunmen dresses as police officers opened fire on them. Sonny jumped in front of Alexis, and he was hit instead of her.
At the hospital, Ned was relieved to see that Alexis was not hurt, and although he had not completely forgiven her for leaving him at the altar, they agreed to work on their problems. That didn't last long, though, and they continually fought. Ned felt that Alexis was choosing her career over him, and Alexis was trying to deal with her fear of commitment and marriage. They decided that the best thing to do was to call it quits to their four-year relationship and go their separate ways. After breaking up with Ned, Alexis channeled all her energies into defending client Sonny Corinthos against his various enemies. They lived across the hall from each other, and their similarly dysfunctional childhoods, along with a tendency to shut people out, caused them to bond.
In summer 2001, Alexis began searching for her long-lost sister, Kristina. Right before Kristin was murdered, she asked Alexis to go hide with baby Kristina. Alexis put the baby in the stables and then returned to the house, where Alexis found her mother dead. Helena had murdered Kristin by slitting her throat. When Alexis went back to the stable, Kristina was gone. With Jax's help, Alexis located her, and they had a joyful reunion, although Kristina soon spent her every waking moment nagging Alexis about her love life.
The main man in that love life was Sonny. Alexis found herself being increasingly goofy and shy in his presence, being hypnotized by his manner and looks, and slowly realized she had fallen in love with him. He played games with her, teasing and flirting, but he had feelings for her as well. Finally, in May 2002, they could no longer contain their emotions and had sex. Unfortunately, Carly saw them and ran out, then got into a car accident, which caused her death. Alexis and Sonny were guilt-ridden, and when Carly returned from the dead several days later--she had kept her status quiet for a period of time after recovering, but told no one about it--Sonny reunited with her.
Alexis stepped away from Sonny and his second chance with Carly. Then she realized she was pregnant with Sonny's baby. Making the circle complete, the next person to find out her secret was Ned. Ned confronted Alexis after he found out she was pregnant when her purse fell on the floor at the hospital and prenatal vitamins fell out. Alexis told him that the baby was Sonny's. Carly also found out by snooping around Mercy Hospital, where Alexis went to get prenatal care because she knew too many people at GH who might learn her condition and leak it back to Sonny. Carly found out Alexis was pregnant and confronted her about it. Alexis couldn't deny she was pregnant, and Carly figured out that Sonny could be the baby's father since their one-night stand together happened a month or so before. Alexis told her eventually but Carly agreed not to tell him, since she feared that Sonny would want to be part of the baby's life and since she was not able to really conceive right then, it was a threat to her own happiness.
Alexis decided to move out of the penthouse and also resign as Sonny's attorney. Sonny found out about her pregnancy and confronted her at her new apartment. Ned happened to be there but in another room. Alexis was speechless when Sonny questioned her about her pregnancy. Ned surprised Alexis when he entered the room and announced that he was the father. Sonny was a little surprised, as well, since Ned was involved with Kristina, but accepted it when Alexis didn't deny it. Sonny left them alone. Alexis decided to continue her prenatal care at GH since Sonny knew she was pregnant.
Alexis' life took a tragic turn when, after lying to Kristina by telling her that Ned was the father of her baby, and hurting her, Kristina found a notepaper taken from Alexis' journal that said that Sonny was the baby's father. Kristina left to find Sonny at his warehouse. Kristina walked into the warehouse and was trapped inside when it was blown up. Alexis got there and Kristina died soon after at the hospital. Alexis found out that the bomb was set up to kill Sonny at his warehouse, but Kristina went there instead.
Alexis blamed Sonny for her sister's death. She also blamed Jason and Roy for being involved with Alcazar's revenge. Alexis poured all her time into her work to stop thinking about Kristina. She got all stressed when she tried to help Luke Spencer with murder charges and ran for District Attorney to keep Scott from getting elected. She suffered from cramps and ended up in the hospital after debating with Scott. Scott dug up her one-night stand with Sonny and questioned her about it after she made cleaning up crime in Port Charles, starting with mob activities, her top priority.
Sonny had a blood test after he found out from Carly that Alexis admitted to her that Sonny was the father. He went to confront Alexis at the hospital about her lie, but the blood test showed that the baby wasn't his. Alexis learned that Ned took precautions and paid a lab person to switch the results. Sonny accepted the test results and left her alone. Alexis continued to try to bring Alcazar down for the death of her sister. When Alcazar was exonerated of all charges, Alexis was devastated and later confronted him when she saw him in the park. Alcazar refused to accept guilt for her sister's death and told her that it was her fault for sleeping with Ned and making her sister go to Sonny for answers. Alexis started to get strong contractions and asked for Alcazar's help. Alcazar refused to help her and left her in the park alone. Alexis couldn't find her cell phone so she could call for an ambulance.
Cameron Lewis found her and took her to GH. She started to go into premature labor and called for Ned. Cameron got Bobbie to get in touch with Ned. Cameron stayed with her until Ned arrived. The doctor told her she had to give birth immediately. Alexis panicked, since it was too soon, but Ned convinced her that she needed to give birth right away. Alexis gave birth to a baby girl, which she already knew. She named the baby Kristina after her sister. The baby had to be put in neonatal intensive care in an incubator and on life support. Alexis refused to leave the baby's side and pushed Ned away in the process. Psychiatrist Cameron Lewis tried to help her with her emotional well-being and allowed her to hold the baby at Christmastime.
Alexis had already pulled out of the D.A.'s race and decided to get back into some work. After agreeing to defend Brenda at Jax's request, Alexis hired Felicia Jones to investigate a witness who was testifying against Brenda for Alcazar's murder. When the trial didn't go well for Brenda and Jason, Alexis decided to bow out of the trial and take Kristina to John Hopkins for surgery. She was also in a custody disagreement with Ned, who she didn't want in her child's life after she caught him kissing a mobster's widow on the docks. Alexis reluctantly agreed to allow Ned to be part of Kristina's life when he threatened to take her to court and reveal Kristina's true paternity.
As Skye Quartermaine and others began to suspect Alexis killed Alcazar, Alexis became more and more unspooled. Cameron caught her going around town in a long red wig. Soon after, she held him and Scott at knifepoint. She was arrested for Alcazar's murder and claimed she had Multiple Personality Disorder, and that her alter, "Kristina," was responsible. Cameron realized she was faking, but kept quiet because of his feelings for her.
Alexis was declared not guilty by reason of mental defect, but paid a heavy price -- Ned was awarded custody and she had to face a long psychiatric treatment. A few weeks later, Edward took custody of the child from Ned, and backstabbed A.J. Quartermaine in the process. A.J. and Skye kidnapped Kristina as revenge. Alexis found her one day and re-kidnapped her, hiding out with her and nursing Kristina back to health even though her actions violated the court order. Her friend, and Cameron's son, Zander, and his Quartermaine girlfriend, Emily, stumbled upon her and agreed to take the baby back to the mansion, and never admitted she had any part in the situation.
Alexis still ached to be close to Kristina. Ned was spending time with the unstable Skye, who hated Alexis and also desperately wanted a family of her own due to infertility. Alexis decided she had to keep an eye on her daughter's welfare. When the Quartermaine butler, Reginald, was injured, Alexis showed up in full drag, including beard, and claimed to be an experienced servant named Dobson. "Dobson" was hired and, over the next few months looked out for Kristina, sparred with Skye, tried to convince Ned to give Alexis a chance at parenthood, and bonded with Emily. Cameron once again found out about this ruse because Alexis was missing her critical court-appointed therapy sessions, and he once again covered for her because of his feelings for her. Finally, Skye colluded with Alexis' therapist--not Cameron--and D.A. Scott to expose Alexis during a big dinner party. They announced plans to arrest Cameron for his part in the cover-up.
Alexis couldn't let a man who had done so much for her take the fall. She whipped off her Dobson disguise, admitted her MPD was a sham, and said Cameron had no knowledge of anything. Scott couldn't get to Alexis because of double jeopardy laws, and Ned blackmailed him into leaving Alexis and Cameron alone. Still, Alexis wanted custody of her daughter and to see her, no matter what anyone said. A restraining order was taken out against her. Kristina was rushed to the hospital and Alexis convinced Bobbie to let her hold the child while Bobbie shut off an alarm. Skye caught her and had her arrested. Alexis felt more isolated than ever, and took a job as Stefan's lawyer in exchange for him helping her get Kristina back. She saw the layers of hate and distrust between him and the boy he had raised--Nikolas--and asked Cameron to treat her -- for real this time -- so she wouldn't pollute her child the way Stefan had.
Eventually Alexis gained custody of her daughter again and began focusing on both her career and her daughter. With little time left for romance, Alexis was extremely irritated when she first found herself the focus of Ric Lansing's attentions. Unfortunately for Alexis, serving as Skye's defense attorney, for the murder of Detective Duncan, she was forced to spend some time with Ric, the prosecuting attorney. Ric, already aware that Sonny was truly Kristina's father, made it a point to seek Alexis out and seduce her. Ric learned quickly that suffocating Alexis with kisses was a quick and effective way of silencing her constant ranting.
It was also at this time that Alexis was confronted by Carly, who was looking at reconciling with her husband, Sonny. Carly wanted to tell Sonny that Kristina was his daughter so the couple could start over without any secrets, but Alexis begged Carly not to tell, and pleaded with her from one mother to another. Carly agreed to keep her secret, but had her reservations. Soon after, Skye was convicted, but Ric and Alexis continued to see one another in work settings, as Alexis went on to defend Faith for a short time, and then Nikolas on several occasions. Eventually the two became more than just enemies who enjoyed the occasional kiss, and a friendship formed.
It was that friendship that helped Alexis stay strong while her daughter faced a life-threatening illness. Alexis had taken several trips to GH with Kristina before Dr. Steven Lars Webber diagnosed her as having a form of leukemia. The only cure for Kristina was a bone marrow transplant with the likely matches--family members. It didn't take long for Steven to discover that Ned was not Kristina's biological father, though all the Quartermaines were tested, anyway, and he confronted Alexis. She refused to admit that Sonny was the father to Steven, but broke down and told Ric, who did not admit that he already knew.
Ric was immediately tested, but was not a match. Even after a confrontation with Carly, Alexis refused to tell Sonny that he was Kristina's father because if that became common knowledge, Kristina's life would continue to be at risk, though instead of leukemia, it would be bullets that killed her. Alexis continued to search for other possibilities while her daughter's situation grew grim. It became clear that Sonny had to learn the truth, but Ric had other plans first. Ric proposed to Alexis, in hopes that their marriage would give Alexis leverage when it came time for a custody battle with Sonny, which was clearly going to happen. But there was a catch--Ric refused to let the marriage be in name only; if they were going to get married, they had to truly try to make the relationship work. Alexis agreed.
At about the same time, Carly was admitting the truth to Sonny, even though she knew that her marriage would end with the confession. Sonny rushed to the hospital, where he confronted Alexis and learned of the impending marriage. It changed little in Sonny's mind and after being tested, Sonny continued to visit Kristina on a regular basis in her hospital room. He often told Kristina how she would come live with him when she was well, and was often chased out of the room by a very angry Alexis. While Alexis didn't want to make Sonny angry, she desperately wanted him to stay away from Kristina. So she begged Ric, who, deciding Alexis needed rescuing, called in a favor and had a restraining order placed on Sonny, to keep him away from Kristina. Hoping to soften Sonny up, Alexis let the restraining order slide on occasion.
In the meantime, all of Sonny's family was tested as possible donors. Not even his son, Morgan, was a match, and things looked worse for Kristina. Steven told Alexis and Sonny that there was another option; Sonny's unborn daughter with Sam McCall could be the answer. The treatment involved harvesting the unborn child's stem cells, found in the umbilical cord. But Kristina didn't have time to wait for the child to be born, so Sonny approached Sam and asked that she consider a two-week early delivery. There was a ten percent risk to the baby, and Sam couldn't justify that risk and refused to help. While Sam understood that Kristina would die, she felt she had to protect her baby first.
When Alexis learned that Kristina's only hope had refused to help, she ran to the chapel, where she found Sam praying alone. Alexis pleaded with Sam at first, but Sam still refused and Alexis lost it, insulting and guilting Sam until finally, in tears, Sam said she would do it. But just as Sam tried to tell Alexis she would do it, she collapsed in excruciating pain. The placenta had broken away from the wall, and Sam's baby would have to be delivered early. Steven tried to ease the tension by explaining that the emergency was not caused by anyone, not even a screaming Alexis. Ric comforted Alexis as she learned that Sam's baby had died, but then urged her to approach Sonny and ask for the lifesaving stem cells. Thinking of Kristina, Alexis worked up the nerve to ask the grieving father to save his other daughter, Kristina. After a heated discussion, Sonny agreed, and the transplant took place.
Kristina's health improved, and Alexis and Ric prepared to fight Sonny in court. As they prepared, Ric received an anonymous tip to visit the docks, where a file containing all the evidence he needed to book Sonny for extortion awaited him on a bench. Ric had Sonny arrested, but never made a copy of the file, which he had placed in a locked file cabinet in his apartment. Carly broke into his apartment and started a fire beneath the file cabinet and it appeared the file had been destroyed. Though his apartment had been blocked off to the public, Alexis managed to sneak in and steal the file, which, aside from a few burns, was in good shape. She used the file to attempt to blackmail Sonny; if Sonny had a change of heart on the stand, she would destroy the file. If he didn't, she would hand the file over to Ric and Sonny would be arrested.
Sonny agreed to Alexis' face, but had no intention of following through on the agreement. The court case began, and while things didn't look so good for Alexis, she felt confident that Sonny would follow through and have his change of heart. As the time came, Ric began asking Sonny the questions Alexis told him he would, but instead of a change of heart, Sonny adamantly proclaimed that Kristina belonged with him. As Alexis handed the file to Ric, Jason held the tape of John Durant admitting he stole the file in the first place, which made the evidence against Sonny inadmissible in court. Alexis begged Ric to prosecute Sonny, anyway, but Ric had nothing without the file. Alexis needed to face the fact that there was a very real possibility that Sonny would get custody of Kristina. Things went very badly for Alexis in court, especially after she tried to kidnap Kristina, but Sonny shocked her by agreeing to share custody.
Alexis and Ric nearly split up after Alexis learned he had known Sonny was Kristina's father from the beginning, and she began to believe he was only using her to get to Sonny, but the two reconciled. Kristina was kidnapped not long after, but Ric never wavered in his faith in Alexis, and convinced Sonny that Alexis had nothing to do with the kidnapping. Alexis also learned she was pregnant with Ric's baby, which left her out of the search for Kristina because she needed to rest. Ric and Alexis managed to rescue Kristina from Faith down in Louisiana, but were devastated to learn of Michael's death. Michael's death and Kristina's kidnapping convinced Alexis that her daughter was better off without Sonny in her life, but when she tried to fight Sonny on the custody, Ric would not go along with her, and when Ric confronted her about not going to therapy like she promised, Alexis realized Ric didn't fully trust her and wanted to separate. Alexis fled to London with Kristina, only to faces charges courtesy of Sonny when she returned. She joined forces with John Durant to bring down Sonny, and was thrilled to overhear Michael confess to Jason that he knew he murdered A.J., as it gave her leverage. After Ric learned that Alexis was draining the Cassadine accounts to bring down Sonny, he washed his hands of her, and drove the wedge even further between them when he insisted that Sonny didn't murder A.J.
Alexis was shocked to learn that Ric had been so adamant in fighting for Sonny because he knew Michael was the real killer and wanted a chance to try again, but Ric couldn't trust that she was finally over her vendetta with Sonny, so they decided to divorce. Things hit a snag when their lawyers wouldn't help them divorce until after the baby was born, so Alexis began pushing Ric to cheat so they could get the divorce quicker. Their marriage took a turn for the better after Alexis experienced trauma in the hurricane and was barricaded at the Quartermaine mansion, with Ric in attendance. Both wanted to reconcile, but still couldn't trust their feelings. Alexis was shocked to learn at Lucky and Liz's wedding that Ric and Reese had a one-night stand while she and Ric were estranged, but in the train accident that followed, Ric and Alexis were able to put all their differences aside as they welcomed their new daughter, Molly, into the world, and decided to really make a go of their marriage.
Ric and Alexis were both taken ill with the encephalitis plague that hit Port Charles. Alexis received an early dosage of the serum, enabling her to be able to go home with the girls, but Ric remained ill. As Alexis worried that Ric wouldn't make it, she confessed a secret to him that she had never told -- when she was sixteen years old, she had given birth to a baby girl, on May 11, 1980--Mother's Day. Mikkos had taken her to a private clinic in Chatham, Maine, then forced her to give her daughter up for adoption. With Ric's help, Alexis decided to search for her long-lost daughter.
Alexis found out that Sam McCall was the daughter she gave up when she was 16. Sam and Alexis had a rocky relationship, and they couldn't agree on Sam's relations with hit man, Jason Morgan. In August of 2006, there was a city-wide blackout. After having a fight with both Ric and Sam, Alexis went home, only to find her husband and daughter having sex on her living room floor. In an attempt to keep Jason from seeing that, she made him take her to the hospital.
She was diagnosed with lung cancer. Thinking she was going to die, she didn't confront Ric and Sam about what they had done, in order to keep her family together. Although Alexis initially refused chemo, she agreed to it in the end. After confronting Ric and Sam, she asked Ric for a divorce and alienated Sam. Ric quickly took Alexis to court in order to get custody of Molly. He even went as far as to arrest Alexis for smoking medicinal marijuana.
While at Wyndemere, Alexis met a charming man who she knew as James Brosnan. Little did she know that James Brosnan was James Craig, the man who blew up the MC, and Jerry Jacks, her ex brother-in-law. After he revealed his true identity, she became his lawyer as a favor to Jax.
Jerry pursued her relentlessly for over a year. She resisted a relationship with him, only indulging in the occasional kiss. In June of 2008, Anthony Zacharra threatened Kristina in an attempt to pressure District Attorney Alexis into releasing his son. Jerry promised Alexis that he would protect her and her daughters, and they made love. Many people, including Nikolas, Ric, Diane, Jax, Carly, and the PCPD, found out about it and expressed their disapproval. Alexis didn't care, however, and continued her affair with Jerry.
The mother-daughter relationship was still tenuous between Sam and Alexis when Sam flirted with Jerry. He told Alexis that Sam was pursuing him and Alexis asked Sam to stay away from Jerry. Alexis found Sam and Jerry kissing in Sam's hot tub. Sam claimed she was trying to find proof of Jerry's misdeeds by stealing his PDA. Alexis believed Jerry instead of her daughter and Sam was arrested when illegal drugs were found at her apartment. Jerry disappeared from Port Charles shortly after.
Mac Scorpio and Alexis worked together when a woman named Brianna Hughes was murdered. Brianna was Mayor Garrett Floyd's mistress and evidence was found that linked the mayor to the crime. When Mayor Floyd was arrested, he publically announced he was being framed by Alexis. Mayor Floyd revealed he had slept with Alexis and she wanted revenge against him because he would not leave his wife to be with her. Alexis claimed she had only slept with Mayor Floyd once, the night she found Sam and Ric together.
Kristina was most affected by having her mother in the spotlight and she doubted her mother had only slept with Mayor Floyd once. E-mails that were supposedly sent by Alexis to the Mayor were made public and they painted Alexis as a scorned woman. The mayor's wife, Andrea Floyd, continued to publically attack Alexis and the women had numerous arguments. Andrea suggested Alexis had been jealous of Brianna and was the murderer. Andrea planted evidence that supported her claim.
Alexis seemed more unstable when she confessed to being the driver in a hit-and-run. Kristina ran Claudia Zacchara off the road, and the accident killed Claudia's unborn child. Alexis confessed to protect Kristina and eventually the charges were dropped. Alexis was also cleared as a suspect in Brianna's murder when Robin Scorpio found evidence that proved Andrea Floyd was the killer.
Alexis was set-up on some dates with Mac Scorpio, courtesy of Robin, Maxie, Molly, Sam, Kristina, and Diane. The group arranged for Mac and Alexis to spend some holidays together and encouraged them to go on a few dates.
While Kristina encouraged Alexis to spend time with Mac, Alexis encouraged Kristina to spend more time with her boyfriend, Kiefer Bauer instead of her brother Michael. Kristina ran away with Michael to Mexico after Claudia's car accident. Alexis regretted her decision to support Kristina's relationship with Kiefer after she learned Kiefer had been abusing Kristina.
Kristina was severely beaten and taken to the hospital. Originally, Kristina claimed Ethan Lovett attacked her but Kristina refused to allow Alexis to press charges against him. Shortly after Kristina was released, Alexis found Kristina unconscious on the floor. Alexis raced Kristina to the hospital. Unbeknownst to her, Alexis hit Kiefer on the way to the hospital and he was killed. Kristina admitted Kiefer had abused her, not Ethan. Kristina said she covered for Kiefer at first because she feared retaliation from him.
Mac was very understanding when Alexis was charged with the hit and run accident that killed Kiefer. She was given community service which outraged Kiefer's parents. They decided to file a lawsuit against Alexis. Diane agreed to represent Alexis. Kiefer's father, Warren Bauer, continued to harass both Alexis and Kristina and threatened to force Kristina to testify at the trial. Alexis was grateful to Mac, Michael, and Ethan when the protected Kristina from Warren when he went on a shooting rampage in the hospital. He had verbally threatened Kristina and aimed a gun at her before he was shot and killed.
Alexis continued to be concerned with how Kristina dealt with the effects of the abusive relationship with Kiefer. Sonny and Alexis often disagreed on how to best help Kristina. Both Molly and Kristina were involved in a bus crash on their way to a ski trip. Kristina was treated for hypothermia, while initially Molly seemed fine. Molly suffered from post-traumatic stress disorder following the crash, and Alexis helped Molly receive treatment.
Alexis agreed to help her favorite ex-husband Jax in his divorce from Carly. Alexis advised Jax not to seek sole custody of his daughter Josslyn, but he did not agree.
Sonny and Alexis disagreed again on how to parent Kristina after Kristina accompanied Ethan Lovett to the Dominican Republic. Molly accidently led Sonny and Alexis to believe Kristina planned to marry Ethan, which prompted Alexis and Sonny to fly to the Dominican Republic to bring her home. Kristina was actually assisting Ethan in obtaining a divorce from his wife Maya Ward. Although Alexis and Sonny did not agree on how to handle Kristina's crush on Ethan, they threw a joint party to celebrate Michael and Kristina's high school graduation.
Kristina continued to pursue Ethan but Alexis was more concerned with Sam's relationship with Jason after the two became engaged. Alexis initially discouraged her eldest daughter from marrying Sonny's mob enforcer but she set her concerns aside and wished Sam and Jason the best.
Alexis also changed her position in the custody battle between Jax and Carly when she decided not to represent Jax. She advised him several times to share custody of his daughter with Carly but he refused. In the end, Carly was awarded full custody after Jax was arrested on drug charges. Jax decided to leave town and Sonny's wife Brenda left with him. When Jax returned to town and briefly kidnapped his daughter Sonny went after Jax because he blamed him for destroying his marriage. Sonny tampered with Jax's plane and it crashed. Jax was presumed dead and Alexis blamed Sonny for the loss of her close friend.
Alexis set her anger with Sonny aside briefly when Kristina passed out after experiencing ongoing bouts of dizziness and neck pain. Alexis was stunned to learn that Kristina required surgery to remove a bone fragment that was pressing on an artery. Molly hypothesized that Kristina's injury could have been sustained months before when Sonny caused Johnny Zacchara's car to explode while Kristina was in close proximity. The cause of the injury could not be pinpointed but Kristina recovered in time to join Alexis and the rest of the family at Sam and Jason's wedding reception.
At the wedding reception, Alexis saw Kristina speaking to Kate Howard about a career in the fashion industry. Alexis did not want Kristina to forgo college to work at Kate's magazine Crimson. Alexis joined forces with Sonny and convinced him that it would be best if Kristina left Port Charles and he arranged for Kristina to be accepted into Yale.
While Kristina moved on to Yale, Diane decided to pursue her writing full time and suggested that Alexis take over legal counsel for Sonny. Alexis refused until Sonny reminded her that she owed him and she was forced to become his attorney even though she still blamed him for Jax's death. Her anger eventually shifted to Carly when she learned that Jax was alive and that Carly had known for months yet had allowed everyone to grieve.
As Alexis was kept busy at work representing the Corinthos organization, she was also busy with her two daughters that remained in Port Charles. Sam revealed that she was pregnant but did not seem enthusiastic about it and was reluctant to tell her mother why. Meanwhile, Molly made a new friend named T.J. and together they hosted an underage drinking party at the lake house. Molly's friend took the blame for the party and Alexis forbade Molly from spending time with him.
The troubles Alexis had with her daughters were placed in perspective after Robin Scorpio was presumed dead after a lab explosion. Alexis tried to offer comfort to Mac and she was able to help him in an unexpected way. After Robin's death, Mac's daughter Maxie Jones confessed to the murder of Lisa Niles and Officer Briggs. Alexis agreed to represent Maxie although there was not much she could do since Maxie insisted on pleading guilty. Alexis also represented Sonny when he was accused of causing a car accident that resulted in the death of a young man and his child. Sonny was acquitted and then he hired Alexis to provide legal counsel for Kate Howard after she assaulted Dr. Ewen Keenan. Alexis successfully defended Kate and cited her dissociative identity disorder as the reason for Kate's lapse in judgment.
After Kate's legal troubles were over, Sonny and Alexis joined forces again in dealing with Kristina's unexpected return from Yale. Kristina arrived with a camera crew and announced that she had dropped out of college after she learned that her parents had used Sonny's leverage to gain her acceptance. Kristina threatened to cut all ties with her family if they did not agree to support her new venture, a reality show entitled "Mob Princess."
Although Alexis was not thrilled with Kristina's new project, her attention shifted to Sam after Molly revealed that Sam was not pregnant with Jason's child, but with a child conceived by rape. Shortly after Alexis learned the details of her grandchild's conception she helped Sam deal with the loss of her child. Sam gave birth to a son in a motel room during a storm but the baby was presumed dead. Alexis rallied her daughters together around Sam as they held a funeral for the baby. Sam's struggles continued after the death of her child as she and Jason drifted farther apart and she decided to live with Alexis.
While Sam's relationship faltered Alexis discovered that Molly had a relationship with her own. She accidently happened upon Molly and her boyfriend T.J. and was furious to realize that Molly had disobeyed her instructions to stay away from him. Eventually the teens and T.J.'s guardian Shawn convinced her to allow Molly and T.J. to date as long as they adhered to specific ground rules. Alexis and Shawn bonded over a game of strip pool while the teens were on a date elsewhere.
After Alexis spent more time with Shawn, she started thinking about him romantically. Around the same time, she developed a dangerously high fever and was hospitalized. Alexis recovered from her mysterious illness and was flattered to learn that Shawn had remained close while she was ill and she agreed to go on a date with him. Their date was postponed when Jerry Jacks returned to town and poisoned the water supply with a deadly toxin. However, Alexis did not have to worry about effects of the toxin because her mysterious illness had actually been the result of an inoculation that Jerry had injected in to her so she would be spared.
Even though Alexis was safe, her loved ones, including Sam and Molly, had been exposed and she feared for their safety. She also worried about Shawn after Jerry knocked him out while he kidnapped her and tried to take her away from Port Charles. Shawn found Alexis and rescued her from Jerry.
Alexis was grateful that Kristina had been out of town during the crisis until she learned that Kristina had been in Las Vegas and had married Trey Mitchell, the producer of her Mob Princess reality show. Kristina explained that she had married Trey as a favor to his father and that they planned to annul the marriage. Alexis and Sonny believed that Trey had taken advantage of Kristina and their suspicions were confirmed after Trey's father was revealed to be an enemy from Sonny's past.
Alexis handled Kristina's annulment and then helped Sam navigate through her feelings for Jason. All of the Davis women were thrilled when Sam's son was revealed to be alive and she reunited with Jason. Sam's happiness was short-lived due to Jason's presumed death and Alexis tried to offer support to her eldest daughter but Sam pushed her away.
Instead, Alexis offered her support to Sonny as he dealt with the loss of Jason and the loss of his fiancée Kate to her alternate personality Connie. Alexis worked with Sonny to find a way to legally commit Connie/Kate for psychiatric treatment. She was dismayed to learn that when the legal system had failed, Shawn had helped Sonny take matters into his own hands. Alexis begged Shawn to stay away from Sonny's organization and admitted that she cared deeply for him. The feelings were mutual and they decided to take their relationship to an intimate level.