
Cam inhales a toxin while performing an autopsy in The Man in the Cell, endangering her life. Following this incident, Booth ended his relationship with Cam after he claimed that relationships at work put everyone at risk when stressful situations occur.
David Boreanaz portrays Seeley Joseph Booth, one of the main characters in Bones. Camille "Cam" Saroyan is played by Tamara Taylor. Cam is introduced in the second season of the series. Seeley Booth and Camille Saroyan have a professional, friendly, and romantic relationship in the series.
Why do Booth and Cam break up?
At some point, Cam puts her life in danger when she accidentally inhales a poison while performing an autopsy. So, Booth broke up with her, claiming that relationships at work put people in danger in dire circumstances. Booth and Cam knew each other before the latter got employment with Bones. The couple dated once before her employment and again when she arrived at the Jeffersonian.
Who is Booth in Bones?

Seeley Joseph Booth is a main character in the series. He is a Special Agent with the FBI and the present FBI liaison to the Jeffersonian. He is portrayed by David Boreanaz in the series.
Booth is originally from Philadelphia but was raised in Pittsburgh. He is 35 years old in Season 3, and Brennan is five years younger than him. In the Women in Limbo episode of Season 1, it is claimed that Brennan was born in 1976, which should have placed Booth's birthday in 1971. In Season 4, the "squints" celebrate his birthday. Booth is described as being in his (early) 40s in season 11, along with his brother Jared. He was an altar boy as a child, speaks a little Latin, and is still a Roman Catholic. He is a religious man by nature.
Who is Cam in Bones?

Camille "Cam" Saroyan is the chief of the Jeffersonian Institute's Forensic Division, a new division established during the summer of 2006. The character is played by Tamara Taylor in the series.
She previously served as New York City's youngest coroner, performing autopsies under challenging and occasionally unsanitary conditions. She confesses to Booth that the Jeffersonian's facilities are the reason she accepted the position. Before becoming a coroner, she spent eleven years as a police officer in New York. The fact that she went from being a police officer to a doctor with a specialization in forensic pathology shows her talents. She is a 'hard line' woman who leads her division and stands up for them when needed, provided she thinks they are right.
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FAQs about Booth and Cam
A. Booth and Cam end their relationship in "The Man in the Cell" episode in season 2 of Bones.
A. Yes, Booth and Cam had a romantic relationship.
A. Booth and Brennan consummate their relationship in the second-to-last episode of season six, and in the final moments of the season finale, it is revealed that Booth is the father of Brennan's child.