Who is Andrew DeLuca in Grey's Anatomy?

Last Modified Apr 10, 2025 18:32 EDT
Who is Andrew DeLuca in Grey's Anatomy?
Andrew DeLuca (Source: ABC)


Andrew DeLuca, portrayed by Giacomo Gianniotti, is a fictional character in the American medical drama series Grey’s Anatomy. DeLuca was introduced as a recurring character in season 11 of the series and was later promoted to one of the main characters in the story by season 12. He left the show as a main character in season 17 of the show.


At the conclusion of Season 11, Andrew was introduced as a brand-new surgical intern at Grey Sloan Memorial Hospital. In Season 13, he was promoted to resident. Andrew developed close relationships with many of the attending surgeons throughout his time on the show, which is uncommon for interns and residents. His story frequently centered on his battles to survive the demands of a cutthroat industry, blend in with his peers, and manage interpersonal interactions with his coworkers.


Grey's Anatomy is an American medical drama that centers on the personal and professional lives of attendings, residents, and surgical interns at the fictional Seattle Grace Hospital, which was subsequently renamed the Grey Sloan Memorial Hospital. The pilot was written by Shonda Rhimes, who also served as executive producer, head writer, and showrunner until her departure in 2015. The show centers on Dr. Meredith Grey (Pompeo) for most of its run, following her journey from surgical intern to fully certified physician to the chief of general surgery at the hospital.


Andrew DeLuca’s background in Grey’s Anatomy


Andrea "Andrew" DeLuca and his mother relocated from Italy to Wisconsin when he was a little boy, while his sister Carina (Stefania Spampinato) remained with their father, Vincenzo DeLuca (Lorenzo Caccialanza). Vincenzo was a well-known Italian surgeon who was also dishonest and mentally ill.


Andrew's mother left with Vincenzo after he exploited his wealth and connections to evade prosecution after operating in a manic state and killing four patients. Eventually, when Andrew's mother went back to Italy to see Carina, she passed away from a stroke.


The DeLucas speak English and Italian fluently. Because of their different upbringings, Andrew speaks Italian with an American accent, while Carina speaks English with an Italian accent. Andrew worked as an EMT immediately after high school before deciding to pursue a career in medicine. He had an unstable relationship with his future coworker Sam Bello (Jeanine Mason) at one point, but it couldn't be resolved when Sam moved away.


Related: When did greys anatomy start


What happened to Andrew DeLuca in Grey’s Anatomy?


Andrew DeLuca, portrayed by Giacomo Gianniotti, left the American medical drama series Grey’s Anatomy. He was killed off in the show’s 17th season.


Who is Andrew DeLuca in Grey's Anatomy
Andrew DeLuca. (Source: Screengrab from the show)


After becoming an attending in Season 17, Andrew seems to have overcome his mental health issues. But in the "Helplessly Hoping" episode, Andrew is stabbed to death by Opal's partner, a human trafficker whom Andrew had previously identified. Andrew's efforts result in Opal's arrest after he follows her and calls the police, but he suffers serious injuries in the process. Despite having surgery at Grey Sloan and recovering at first, Andrew codes during a follow-up procedure, and his time of death is announced at 22:50. Andrew shows up on a beach in Meredith's COVID-19-induced "afterlife" dream sequence, where he bids Meredith farewell and is reunited with his mother, who has passed away.


Who played Andrew DeLuca in Grey’s Anatomy?


Who is Andrew DeLuca in Grey's Anatomy?
Giacomo Gianniotti. (Source: Instagram)


Giacomo Keaton Gianniotti is an Italian-Canadian actor who was born on June 19, 1989, in Rome, Italy. Gianniotti portrayed Dr. Andrew DeLuca in the medical drama series Grey's Anatomy from 2015 until 2021.


For the final two episodes of the eleventh season of Grey's Anatomy, Giacomo Gianniotti was cast as Dr. Andrew DeLuca, a surgical intern. He received a promotion to series regular on January 8, 2016, for season 13. Gianniotti's performance earned him the Tell-Tale TV Award for Favorite Actor in a Network Drama Series in 2021.




FAQs about Andrew DeLuca in Grey’s Anatomy

A. Andrew DeLuca, portrayed by Giacomo Gianniotti, left the American medical drama series Grey’s Anatomy. His departure was marked by his death in the show’s 17th season.

A. Andrew had a romantic relationship with Meredith Grey (Ellen Pompeo) for a short period. They eventually broke up.

A. DeLuca's manic episodes began to interfere with his work around Season 16, which made it clear that he was in the early stages of bipolar disorder.

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