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5) Ellen Pompeo (Grey's Anatomy)
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Ellen Pompeo is the reigning queen of Television. Be it drama or romance, she has done it all and done it perfectly. Her portrayal of Meredith Grey in Grey's Anatomy is still one of the most beloved characters. Pompeo's Meredith had many love interests throughout the show, but her romantic on-screen chemistry with Patrick Dempsey's Dr. Derek Sheperd is the most iconic.
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