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7) Patrick Dempsey as Dr. Derek Shepherd in Grey's Anatomy
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Patrick Dempsey’s beloved portrayal of Dr. Derek "McDreamy" Shepherd almost didn’t happen. The role was initially offered to Rob Lowe, but Lowe turned it down, citing personal reasons. This opened the door for Dempsey, whose charisma and on-screen chemistry with Ellen Pompeo (Meredith Grey) helped elevate Grey’s Anatomy to one of the most successful medical dramas ever. Dempsey's portrayal of the charming neurosurgeon became an iconic TV character, solidifying him as a major television star.
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Edited by Anshika Jain
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