Rosie O’Donnell credits Mounjaro for continued weight loss and says her new size feels unreal

Rosie O'Donnell, an actress and comedian, recently posted about her weight loss process matter-of-factly. She is 62 years old and has noticed significant changes in her health and appearance since she started treatment with Mounjaro, a drug approved for the treatment of type 2 diabetes.

While the main target of the drug is to control blood sugar, Rosie has noted that one of the side effects is weight loss. In addition to the medication, she has also changed her daily habits—preparing her food and altering her diet—to cater to her needs.

Through these shifts, she has experienced concrete changes in her overall health, impacting her looks and the way she perceives herself. By sharing her experience publicly, Rosie gives an unbiased description of how lifestyle changes and medication can be used in combination.

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Rosie O'Donnell's experience with Mounjaro and its impact on her weight

Rosie O'Donnell has been taking Mounjaro, a drug that is meant for type 2 diabetes, to control her health. She pointed out that one of the side effects of this medication is weight loss—a factor that she has personally benefited from.

In a TikTok video posted on March 2025, Rosie stated:

"I'm on Mounjaro for diabetes and one of the side effects is you lose weight," a very down-to-earth statement regarding the drug's effect on her.

This explicit observation highlights the simple truth of her experience. The emphasis is still on her own health experience and not some advertising message, indicating her advancement as a statement of fact.

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How lifestyle modifications have aided her health gains

Besides taking Mounjaro, Rosie has implemented lifestyle modifications which contributed to her health gains. After moving to Ireland with her 12-year-old child, Clay, she took on the responsibility of preparing her own meals instead of having a personal chef.

This adjustment permitted her to have more control over what she ate; such as limiting sugar consumption and eating regular, home-cooked meals. Rosie has discussed these changes in her daily life, stating that they have brought about better sleeping and feelings of overall well-being. Her comments are an obvious demonstration of how daily habits can promote overall health.

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Her response to changes in clothes size and self-image

Rosie also discussed how the physical changes of her weight loss affected her self-image. She made this comment on a TikTok video:

"I'm one of those people who always had a weight issue and now that I'm a size large. I was surprised."

This quote illustrates that the adjustment in her wardrobe size has been sudden and profound, evoking a reevaluation of how she perceives herself.

The adjustment in her wardrobe has become a physical indicator of her progress, her genuine response as a surprise highlights that these changes are not scripted but personal. Her narrative is still objective, centering on the fact of her experience without embellishment.

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Rosie O'Donnell's recent weight loss journey highlights the synergistic impact of medication and lifestyle modifications. Her experience with Mounjaro and adopting a healthier lifestyle has brought significant changes to her health and self-image.

Through her story, O'Donnell not only celebrates her success but also inspires others who are working through their own health issues.