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Lady Gaga’s Disease track has amassed 200 million streams on Spotify. The Dark Pop/electro-pop song has become the singer’s 26th track to achieve this milestone.
Disease was released on October 25, 2024, making its accumulated 200 million streams even more impressive. Disease, which talks about the healing qualities of love, has 202, 121 and 456 streams and a daily stream count of 834, 706 as of the time of writing.
Disease sits below Gaga's I’ll Never Love Again and Perfect Illusion at 235, 313, and 809 and 231, 330, and 101 streams, respectively.
Other Lady Gaga tracks with 200 million streams and more include:
- Shallow
- Die With A Smile
- Poker Face
- Always Remember Us This Way
- Bad Romance
- Just Dance
- Rain On Me
- Million Reasons
- Telephone
- Judas
- Paparazzi
- Born This Way
- Applause
- Bloody Mary
- Alejandro
- LoveGame
- Stupid Love
- I’ll Never Love Again—Film Version
- Sour Candy
- The Cure
- Hold My Hand
- The Edge of Glory
- Abracadabra
- I’ll Never Love Again—Extended Version
- Perfect Illusion
More details on Lady Gaga’s Disease song explored as it exceeds 200 million streams on Spotify
Disease was launched as the lead single from Mother Monster’s highly anticipated album Mayhem. The track is reminiscent of the singer’s earlier releases like Bad Romance and Judas and explores melodramatic lyrics and dark imagery.
In the pre-chorus, Lady Gaga suggests that she is the antidote that her lover desperately needs and teases them with it:
"(Ah-ah) Screaming for me, baby(Ah-ah) Like you're gonna die/ (Ah-ah) Poison on the inside/ I could be your antidote tonight/ (Ah-ah) Screaming for me, baby/ (Ah-ah) Like you're gonna die/ (Ah-ah) Poison on the inside/ I could be your antidote tonight,"
In the song's chorus, the singer expresses that she is ready to cure her lover and play doctor:
"I could play the doctor, I can cure your disease/ If you were a sinner, I could make you believe/ Lay you down like one, two, three/ Eyes roll back in ecstasy/ I can smell your sickness, I can cure your (Cure)/ Cure your disease,"
The multi-genre song was written and produced by Gaga alongside Andrew Watt, Henry Walter, and her fiancé, Andrew Polansky. The song peaked at number 14 on the Billboard Global 200.
The music video was released on October 30, 2025, and the singer played six versions of herself. Lady Gaga spoke on the video’s concept, describing it as being about facing her fear and embracing the parts of herself she cannot change:
"Disease is about facing that fear, facing myself and my inner darkness, and realizing that sometimes I can't win or escape the parts of myself that scare me. I can try and run from them, but they are still part of me. I can run and run, but eventually, I'll meet that part of myself again, even if only for a moment."
The video boasts 37 million views on YouTube.
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Lady Gaga is set to begin her Mayhem Ball on July 16, 2025, at the T-Mobile Arena in Paradise, United States. The tour is in promotion of the Mayhem album and will conclude on December 12, 2025, in Accor Stadium, Sydney, Australia.
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