Novocaine cast and character guide: Who plays whom in the action comedy film?

The filmmaking pair Dan Berk and Robert Olsen's latest directorial Novocaine has made its released on 14th March, 2025.

This action-comedy film follows the plot of Nathan, who is born with an unusual condition. It prohibits him from feeling any painful sensation on his body.

However, when his girlfriend gets abducted by bank robbers, he fights tooth and nail to rescue her, using his physical condition to his advantage.

Novocaine has received a favourable rating of 7.1/10 at IMDb and an aggregate of 81% at Rotten Tomatoes.

Novocaine has a talented cast of actors, including Jack Quaid, Amber Midthunder, Jacob Batalon, and many others.

Let us find out more details about the incredible cast and the characters they essay in Novocaine.

Novocaine cast and character guide: Who plays whom in the action comedy film?

1) Jacob Batalon as Roscoe

In Novocaine, actor Jacob Batalon essays the role of Roscoe. He is a close buddy of Nathan in the movie. Roscoe was initially a virtual friend of Nathan.

However, due to the kidnapping of Nathan's partner Sherry, these two friends meet in the real world, as Roscoe helps him in finding Sherry.

Jacob Batalon is well known for his work in films and series including Spider-Man: Homecoming (2017), Avengers: Infinity War (2018), Avengers: Endgame (2019), Spider-Man: No Way Home (2021), Reginald the Vampire (2022-2024), Lift (2024), etc.

2) Amber Midthunder as Sherry

Amber Midthunder is portraying the role of Sherry in Novocaine. She works with Nathan and is also his lover. However, in the film, during a heist incident at their workplace, she is held captive by the heist members.

Amber Midthunder has previously worked in films and series including The Originals (2016), Legion (2017-2019), The Ice Road (2021), Prey (2022), Reservation Dogs (2022), Avatar: The Last Airbender (2024), Opus (2025), and many more.

3) Jack Quaid as Nathan "Novocaine" Caine

For the role of Nathan, we have none other than, Jack Quaid!

Nathan, as he is seen narrating in the trailer of the film- "I am just a regular guy, with a regular job", works at a bank. His partner, Sherry, works with him. However, during a heist incident at this bank, he is out to rescue his girlfriend from those robbers.

Nathan is born with a unique condition, due to which he feels no pain in his body.

Jack Quaid is recognised for his work in films and series including The Hunger Games (2012), Logan Lucky (2017), The Boys (2019-present), Batman: The Long Halloween: Part One (2021), Scream (2022), Spider-Man: Across the Spider-verse (2023), Oppenheimer (2023), Companion (2025), and many more.