George Lowe Health struggles explored as Iconic Cartoon Network actor and voice of Space Ghost passes away

George Lowe, the iconic voice behind the Space Ghost, passed away on 2nd March, 2025 after long-standing health struggles. The 67-year-old’s rep confirmed the news to Deadline, while his longtime friend, DJ Marvelous Marvin Boone, also posted about his death on Facebook.

Before his death, the voice actor-comedian reportedly had some health-related issues. George Lowe was in a nursing home for some time in 2023 and was also hospitalized due to declining health. His illness also forced him to stay away from social media, which sparked concerns among the fans.

Christopher “Mc Chris” Ward IV – a rapper, comedian, voice actor, and an admirer of George – checked on the Space Ghost actor. He revealed that Lowe had an aortic dissection earlier in 2023. A Facebook post from Ward read,

“He’s actually had some health problems, had a bad february [2023] after having an aortic dissection and he had to be intubated twice and we came close to losing him. he’s been in a nursing home and rehab and has had to return to the hospital as well to get his medication corrected. he now has a nurse looking after him in his home in florida.”

Per the Mayo Clinic, aortic dissection is a heart-related condition involving a tear in the aorta. MC Chris further revealed in his post that Lowe was improving as of July 2023.

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Fans pay tribute to Adult Swim icon George Lowe after the Space Ghost voice actor passes away at 67

The Space Ghost Coast to Coast star reportedly passed away due to complications of his health struggles. Many of his fans paid tribute to the host of the animated parody talk show on social media.

“RIP a cartoon that never stopped being funny 💔,” a user wrote.

“Damn it. // RIP Mr. Lowe. You brought us years of joy. ❤️ // "You should really get one of these on your show. Oh, wait. You don't have a show,”” another used a quote from Space Ghost Coast to Coast.

“I met George in 2004. Didn't have a camera back then but he taught me the coolest handshake ever. // "This is what the kids in Atlanta do." // I still use it to this day. // Rest easy, George,” someone recounted their meeting with the voice actor.

“Absolute legend, he will be missed by all,” another user added.

A user praised George Lowe,

“Just gutted to hear this. He absolutely was one of the funniest people I had the pleasure of conversing with. 🥺😭”

Another user shared,

“This guy was a part of the core development of my personality, rip George.”

Someone penned down,

“Rest easy, sir! You've more than earned it! Thank you for all the amazing memories. You most certainly will not be forgotten! 💔😥”

George Lowe’s longtime friend, Marvelous Marvin Boone, also posted about his passing on Facebook. Boone posted a picture with the voice actor and shared his sadness,

“I'm beyond devastated. My Zobanian brother and best friend for over 40 years, George Lowe, has passed away after a long illness. A part of me had also died.

Boone continued,

He was a supremely talented Artist and Voice actor. A true warm hearted Genius. Funniest man on Earth too. I've stolen jokes from him for decades. He stole some of mine. He was also the voice of Space Ghost and so much more. Pweeloto.

MC Chris shared an old interview with “hero,” and penned down,

“So bummed to report we lost george. rest in peace my hero. reply with your favorite space ghost line then watch this interview i did with george while i was touring. he is the epicenter of infinite universes and will be missed greatly.”

Clyde W. McCain, another friend of George Lowe, shared various pictures and memories of the Perfect Hair Forever voice actor on Facebook. He wrote down,

"This one is hard one to get through… One of the disadvantages of living over seventy-five years is having to say goodbye to loved ones and close friends. I lost both this week."

George Lowe, who had a decades-long career, last worked in 2024. He voiced his cameo as Space Ghost in Jellystone!’s episode “Space Con.”