Colossal Biosciences, a renowned startup, is popular for its impressive and attentive work on de-extincting extinct wildlife. According to a CBR report, the brand used advanced technology to form a Woolly Mouse. It is a crucial step to resurrect the extinction of the Woolly Mammoth.
The company recorded spectacular results in creating dire wolves that reportedly vanished around 12,500 years ago, according to a CNN report. Colossal Biosciences stated that the newly created species is the "world’s first successfully de-extincted animal."
Colossal Biosciences' co-founder and CEO, Ben Lamm, spoke with CBR and shared how the Game of Thrones author, George R.R Martin, teared up after seeing the dire wolves.

Lamm said about Martin,
"He completely cried."
Colossal Biosciences co-founder shared George R.R Martin's heartfelt reaction to the newly created dire wolves
In a conversation with the previously mentioned outlet, the co-founder recalled George's response to seeing the cloning of live dire wolves that were a fictional portrayal in the world-renowned Game of Thrones series.
The scientists working in this startup formed and saved these animals with the help of gene-editing technology, cloning, and ancient DNA. The critical scientific methods played a significant role in modifying a gray wolf's genes accordingly.
In comparison to the recently formed wolves, dire wolves "had a slightly wider head, light thick fur and stronger jaw."

Reminiscing about the moment when Martin saw these wolves, the Colossal Biosciences co-founder shared,
"I did fly George out to meet the Wolves, and he cried! He completely cried. He said this was like one of the greatest things that he's ever seen."
In addition to wolves, the startup's regenerating projects include working on the dodo, mammoth, and Tasmanian tiger. The scientists have been devoted to planning and executing since 2021.
Per the CNN report, Ben stated a statement mentioning,
"This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works."
The co-founder and CEO of the Texas-based lab further continued,
"Our team took DNA from a 13,000 year old tooth and a 72,000 year old skull and made healthy dire wolf puppies."
Teams behind these innovative projects found noteworthy results. They welcomed two male dire wolf pups on October 1, 2024, making them the world's first de-extinct animals. They were named Romulus and Remus. Later in 2025, a female pup, Khaleesi, was born on January 30.
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