20) James Franco in Knocked Up (2007)
James Franco has made a number of brief appearances during his career, ranging from Justin Lin's small-budget mockumentary Finishing the Game to the 2011 action-comedy The Green Hornet. However, in 2007, Franco portrayed himself in a funny scene for the Seth Rogen/Katherine Heigl romantic comedy Knocked Up. Franco shows up on set to participate in an interview about Spider-Man 3 when Heigl's character talks loudly in front of him because of her pregnancy. As if the scene could not capture more of the late 2000s vibe, Franco jokes, "If this is one of those prank shows, I'm not interested," alluding to shows like Punk'd that were incredibly popular back then.
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Edited by Apoorva Jujjavarapu