4. Michael Scofield (Prison Break)

Michael Scofield's brilliance was the only thing that saved him in Prison Break. From escaping the supposedly unescapable Fox River Penitentiary to battling life-threatening conspiracies, he relied on his brains to outsmart foes. Season 5 proved that Michael staged his death and survived years of captivity, showing that his strength was not just physical but also emotional. His tearful reunion with Sara and Lincoln proved that his strength wasn't just physical but also emotional. Michael is a character of constant survival against all odds, thus making him one of the smartest and most determined characters on TV.
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