In Naruto, Hashirama Senju’s cells are known for their regenerative properties and immense chakra. So when Naruto and Sasuke had their final fight after the Fourth Great Ninja War and lost their arms in the process, many fans assumed he would accept a prosthetic arm enhanced by Hashirama’s DNA, just like how Naruto did. But Sasuke deliberately chose to opt out of it.
Sasuke’s refusal to take Hashirama’s cells is rooted in guilt, redemption, and a deep understanding of his flaws. He realized that after all the destruction and pain he had caused, he needed to repent for his mistakes. In his eyes, the lack of an arm was a form of penance, and a constant reminder for him as it is a direct consequence of the past.
Why didn't Sasuke accept the help he was offered?
At the end of the Fourth Great Ninja War, Naruto and Sasuke faced off one last time at the Valley of the End. The result of this battle looked like a draw, but that was far from the truth. Naruto won as he managed to finally rescue Sasuke from the deep emotional turmoil he was facing within himself. All these years of Sasuke’s desire for revenge was extinguished, and he was allowed to return to their village.
But Sasuke turned him down not with any malicious intent, but out of shame. The memories of his crimes were still fresh in his mind. He knew he had committed countless crimes against Konoha and the world. Sasuke had joined Orochimaru, abandoned his friends, killed the interim Hokage Danzo, and even tried to become the new leader of the revolution after the war.

Instead of accepting the offer to come back, Sasuke chooses to live a life of self-imposed exile. He swore he would protect Konoha from shadows, similar to what his brother Itachi once did. This action stems from his need to atone for his actions. Therefore, Sasuke did not feel worthy of walking freely in the village he tried to destroy, let alone accepting an enhancement using the DNA of the most revered Hokage.
Additionally, Sasuke’s refusal was also a way of holding himself accountable. The arm offered to him wasn’t just a medical solution—it was a gift, a symbol of trust, and a chance to fully reintegrate into the shinobi world. He purposefully kept his body incomplete as this was a conscious decision to live with the scars of his past.
Another reason he chose not to accept help or to enter the village was the political tension surrounding him. Even if some people knew about him being a changed person, he knew it would be very difficult to regain trust in the eyes of those living in the village.
If he suddenly reappeared in Konoha with a new arm enhanced by Hashirama’s DNA, the other villages would likely see it as a threat. It could even lead to civil war, therefore, it was not worth it for him to gain an arm at the cost of possibly another war.
In contrast, Naruto did accept the prosthetic arm as he continued his journey of becoming the Hokage. Both of them represent two halves of the same legacy. Naruto is the public hero, guiding the next generation into the future. Sasuke is the shadow, watching from afar, making sure the peace stays intact. The choices both made represent the burdens they carry in different ways.
What is Sasuke's fate at the end of Naruto?

After refusing the prosthetic arm made from Hashirama’s cells, Sasuke Uchiha began a long journey of redemption and self-discovery. As he left the village, Sasuke traveled to understand the roots of conflict and ensure the mistakes of the past wouldn’t be repeated. He also investigated Kaguya’s legacy and kept an eye on threats that might endanger the peace Naruto worked so hard to create.
Sasuke also married Sakura, and they have a daughter, Sarada. Despite Sasuke’s long absences, he deeply loves his daughter. He also takes on the new role of becoming Boruto’s teacher. Sasuke gave him lessons in combat, chakra control, and understanding the world’s darker realities.
To summarize the events, Sasuke refused Hashirama's cells for selfless reasons. Sasuke’s story arc finally concludes as he is on his way to redeem himself. Not for fame or power but because he feels it is the right thing to do. The first step he took in his journey for atonement was refusing to get a prosthetic arm. This action alone is enough for viewers to understand how much he has grown as a person through the series.