Though a newcomer to the world of daytime television, Huffman's acting portfolio contains an impressive roster of Broadway work. In addition to her Tony Award-winning role in The Producers, Huffman has also appeared on La Cage aux Folles, Big Deal, The Will Rogers Follies, Steel Pier, and Short Talks on the Universe. Huffman's work in The Will Rogers Follies earned her a Tony nomination in 1991. Huffman has also appeared as an Ednaette in Dame Edna's Royal Tour.
Huffman has also appeared in a handful of motion pictures, including Romance & Cigarettes, Sunday on the Rocks, and Space Marines.