Non-nonsense nurse Epiphany Johnson is a force to be reckoned with. A full-figured woman who speaks her mind and doesn't mince words, Epiphany is quite intimidating. She is a dedicated nurse who doesn't tolerate anyone giving less than 110%. She will call out doctors and nurses alike, when she feels that they are being less than professional. She has a strong moral compass that was never tested more than when her only son, Stanford, decided to go to work for mob boss, Sonny Corinthos. Epiphany strongly disapproved of her son squandering his education on spying for the mob. Despite her objections to Stan's career choices, Epiphany loved her son fiercely and never stopped trying to convince him to make different choices. Sadly, Epiphany would see her greatest fear realized when, during a phone call with Stan, she heard him killed in a mob-ordered hit. The pain of losing her son in such a violent manner took its toll on Epiphany.
In February 2008, Epiphany suffered a serious heart attack and collapsed in the hospital locker room. She had just received her son's cremated ashes and was clutching them in her hands when they found her. Luckily, the doctors were able to save her life. Epiphany made a full recovery and kept up her reputation of keeping both doctors and nurses in line around the hospital.
Epiphany was especially outraged with the hospital gossip and unprofessionalism when her colleague doctor Patrick Drake had an extramarital affair with another doctor on staff, a doctor Lisa Niles. Patrick's wife Robin, also a doctor at the hospital, and Lisa often feuded, even in front of patients. Epiphany frequently reprimanded the trio and reminded them to keep their personal business private.
However, Epiphany showed her softer side after Robin was presumed deceased. Patrick was overcome with grief and he turned to pills. Epiphany refused to let Patrick grieve alone and she provided him with a combination of tough love and friendship that helped him get his life back on track.
As a tribute to Patrick’s wife Robin and others with HIV, Epiphany participated in the resurrected Nurses Ball and developed a crush on another performer, Milo Giambetti. She believed her feelings were unrequited until Milo asked her out and they began dating.